Lyons JM

No ORCID on file · 3 papers in corpus · active 2006-2016
2016
TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.
Pathogens and disease ·doi:10.1093/femspd/ftv107

Chlamydia trachomatis infections demonstrate remarkable differences in clinical course that are approximately 40% based on host genetic variation. Here, we study the single nucleotide polymorphisms (SNPs) and their haplotypes in TLR2, TLR4 …

2009
TLR9 KO mice, haplotypes and CPG indices in Chlamydia trachomatis infection.
Drugs of today (Barcelona, Spain : 1998) ·doi:10.1358/dot.2009.45.2.1322478

Previous studies have investigated the role of Toll-like receptor (TLR)2 and TLR4 in susceptibility to and severity of Chlamydia trachomatis infections. In this study we employ a unique integrated approach to study the role of the intracell…

2006
Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women?
BMC infectious diseases ·doi:10.1186/1471-2334-6-122

BackgroundIn women, Chlamydia (C.) trachomatis upper genital tract infection can cause distal tubal damage and occlusion, increasing the risk of tubal factor subfertility and ectopic pregnancy. Variations, like single nucleotide polymorphis…