Germaine M. Buck Louis

Increasing evidence supports an early origin for health and disease, including gynecologic disorders, possibly the result of environmental exposures during critical or sensitive windows of human development. This chapter discusses the weigh…

OBJECTIVE: To estimate the incidence of endometriosis in an operative cohort of women seeking clinical care and in a matched population cohort to delineate more fully the scope and magnitude of endometriosis in the context of and beyond cli…

Background and Aims: Persistent organic pollutants (POPs) have been associated with endometriosis, though with equivocal results possibly reflecting choice of biospecimen. We sought to assess this ...

An evolving body of evidence suggests an adverse relation between persistent organochlorine pollutants (POPs) and menstruation, though prospective longitudinal measurement of menses is limited and served as the impetus for study. We prospec…

BACKGROUND: Understanding the health effects associated with environmental chemicals is challenging when individuals have concentrations at or below the laboratory limits of detection as well as when the values may round to zero or are pres…

Limited study of persistent organochlorine pesticides (OCPs) and endometriosis has been conducted. One hundred women aged 18-40 years who were undergoing laparoscopy provided 20 cm(3) of blood for toxicologic analysis and surgeons completed…

MikolajczykPrevious research has described variability in menstrual cycle lengths within and across women, though less attention has focused on characterising patterns of bleeding. While clinical definitions for menstrual bleeding are often…

BACKGROUND: Intrauterine environmental exposures have been adversely associated with male reproductive health in contrast to limited investigation of such exposures and female reproductive health. METHODS: To address this research gap, a c…

Müllerianosis may be defined as an organoid structure of embryonic origin; a choristoma composed of müllerian rests--normal endometrium, normal endosalpinx, and normal endocervix--singly or in combination, incorporated within other normal o…

An increasing body of evidence suggests that environmental exposures are adversely influencing female fecundity and fertility. Endocrine-disrupting compounds (EDCs) are of particular concern, due to their ability to interfere with the body'…

OBJECTIVE: To determine whether body size and perceived figure, both current and historical, are associated with a diagnosis of endometriosis on laparoscopy. DESIGN: Cohort study of consecutively identified patients undergoing laparoscopy …

There is mounting evidence that endometriosis may have an environmental origin, possibly exposure to hormonally active agents such as dioxin and other compounds that bioaccumulate. Among candidate materials are polychlorinated biphenyls (PC…

BACKGROUND: Hormonally active environmental agents have recently been associated with the development of endometriosis. METHODS: We undertook a study to assess the relationship between endometriosis, an estrogen-dependent gynaecological di…

Endometriosis is an estrogen dependent gynecologic disorder affecting approximately 10% of females of reproductive age. Its etiology remains elusive though hormonal and immunological factors have been postulated as underlying mechanisms. Of…

STUDY OBJECTIVE: To assess health and fertility status among women after surgical treatment of endometriosis. DESIGN: Prospective study. SETTING: Community-based gynecologic specialty practice. PATIENTS: Two hundred ninety women with new…

We suggest that müllerianosis is a distinct form of endometriosis, separate in its pathogenesis from transplantation endometriosis of lymphatic, hematogenous, transtubal, or iatrogenic origin, and also distinct from endometriosis of coelomi…