Rakonczay Z Jr

No ORCID on file · 4 papers in corpus · active 2008-2025
2025
High concentrations of L-lysine cause mitochondrial damage and necrosis in isolated pancreatic acinar cells.
Scientific reports ·doi:10.1038/s41598-025-29890-7

Intraperitoneal administration of high doses of basic amino acids, such as L-lysine (L-Lys), L-arginine (L-Arg) or L-ornithine (L-Orn) induces acute pancreatitis in rodents. Although the exact mechanism of their action is not fully understo…

2020
Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis.
Scientific reports ·doi:10.1038/s41598-020-74943-8

The main causes of acute pancreatitis (AP) are biliary disease, alcohol consumption, hypertriglyceridaemia (HTG) and endoscopic retrograde cholangiopancreatography (ERCP). The aim of this meta-analysis was to evaluate the effects of these a…

2013
Variants in CPA1 are strongly associated with early onset chronic pancreatitis.
Nature genetics ·doi:10.1038/ng.2730

Chronic pancreatitis is an inflammatory disorder of the pancreas. We analyzed CPA1, encoding carboxypeptidase A1, in subjects with nonalcoholic chronic pancreatitis (cases) and controls in a German discovery set and three replication sets. …

2008
The role of NF-kappaB activation in the pathogenesis of acute pancreatitis.
Gut ·doi:10.1136/gut.2007.124115

Acute pancreatitis is an inflammatory disease of the pancreas which, in its most severe form, is associated with multi-organ failure and death. Recently, signalling molecules and pathways which are responsible for the initiation and progres…