Nick Pullen

No ORCID on file · 5 papers in corpus · active 2008-2012

Study types

  • article 2
  • book-chapter 1
  • other 1
  • review 1

Condition tags

  • endometriosis 5
  • chronic_pelvic_pain 2
  • infertility 1
book-chapter 2012
Progesterone Resistance and Targeting the Progesterone Receptors: A Therapeutic Approach to Endometriosis
·doi:10.5772/29021

Endometriosis is characterised by the benign growth of endometrial glands and stroma on the surface of peritoneal tissues and other organs. It is generally regarded as an aberrant estrogen-dependent growth condition, which presents with sym…

article 2011
Cellular Exchange in an Endometriosis-Adhesion Model Using GFP Transgenic Mice
Gynecologic and obstetric investigation ·doi:10.1159/000325826

BACKGROUND: Endometriosis is a debilitating disease that affects women of reproductive age and may lead to impaired fertility. Cell attachment, invasion of the underlying tissue, and vascular ingrowth are important processes in endometrial …

review 2011
The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies
Human reproduction update ·doi:10.1093/humupd/dmr030

BACKGROUND: Endometriosis is a benign gynaecological condition that presents symptoms of chronic pelvic pain and the ectopic growth of endometrial lesions at sites on the peritoneum. Few new approaches to the management of the disease sympt…

article 2011
The Translational Efficacy of a Nonsteroidal Progesterone Receptor Antagonist, 4-[3-Cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy,-2,6-dimethylbenzonitrile (PF-02413873), on Endometrial Growth in Macaque and Human
The Journal of pharmacology and experimental therapeutics ·doi:10.1124/jpet.111.183848
other 2008
The translational pharmacology of a novel, potent, and selective nonsteroidal progesterone receptor antagonist, 2-[4-(4-cyano-phenoxy)-3,5-dicyclopropyl-1H-pyrazol-1-yl]-N-methylacetamide (PF-02367982)
The Journal of pharmacology and experimental therapeutics ·doi:10.1124/jpet.108.140467

The progesterone receptor (PR) is an important regulator of endometrial function. Blockade of PR function has been recognized as the potential basis for preventing gynecological conditions such as endometriosis and uterine fibroids. In this…