Lanz RB

No ORCID on file · 7 papers in corpus · active 2013-2024

Study types

  • other 2
  • article 1

Condition tags

  • endometriosis 3
  • infertility 2
other 2024
A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis
Nature communications ·doi:10.1038/s41467-024-46180-4

Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums fo…

2020
Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms.
Science signaling ·doi:10.1126/scisignal.aaz9646

Differences in the relative abundances of the progesterone receptor (PGR) isoforms PGRA and PGRB are often observed in women with reproductive tract cancers. To assess the importance of the PGR isoform ratio in the maintenance of the reprod…

2018
SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.
Nature communications ·doi:10.1038/s41467-018-06652-w

Mammalian pregnancy depends on the ability of the uterus to support embryo implantation. Previous studies reveal the Sox17 gene as a downstream target of the Pgr-Gata2-dependent transcription network that directs genomic actions in the uter…

2016
A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function.
Cell reports ·doi:10.1016/j.celrep.2016.09.093

Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 (Gata2) are infertile, showing failures in embryo implantati…

2015
FOXO1 is required for binding of PR on IRF4, novel transcriptional regulator of endometrial stromal decidualization.
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2014-1292

The forkhead box O1A (FOXO1) is an early-induced target of the protein kinase A pathway during the decidualization of human endometrial stromal cells (HESCs). In this study we identified the cistrome and transcriptome of FOXO1 and its role …

other 2014
The epidermal growth factor receptor critically regulates endometrial function during early pregnancy
PLoS genetics ·doi:10.1371/journal.pgen.1004451

Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pre…

article 2013
COUP-TFII Regulates Human Endometrial Stromal Genes Involved in Inflammation
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2013-1191

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2) is an orphan nuclear receptor involved in cell-fate specification, organogenesis, angiogenesis, and metabolism. Ablation of COUP-TFII in the mouse uterus causes …