Science signaling

· 2 papers in corpus

2020

Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms.

doi:10.1126/scisignal.aaz9646 ·PMID:33023986

Differences in the relative abundances of the progesterone receptor (PGR) isoforms PGRA and PGRB are often observed in women with reproductive tract cancers. To assess the importance of the PGR isoform ratio in the maintenance of the reprod…

2015

Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function.

doi:10.1126/scisignal.aaa1977 ·PMID:26012634

Phosphorylated residues occur preferentially in the intrinsically disordered regions of eukaryotic proteins. In the disordered amino-terminal region of human α-actinin-4 (ACTN4), Tyr(4) and Tyr(31) are phosphorylated in cells stimulated wit…