Vikas Gupta

ORCID: 0000-0002-1419-8607 · 10 papers in corpus
article 2023
Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study
·doi:10.1016/s0140-6736(22)02036-0

BackgroundJanus kinase (JAK) inhibitors approved for myelofibrosis provide spleen and symptom improvements but do not meaningfully improve anaemia. Momelotinib, a first-in-class inhibitor of activin A receptor type 1 as well as JAK1 and JAK…

article 2023
Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis previously treated with a JAK inhibitor (MOMENTUM): an updated analysis of an international, double-blind, randomised phase 3 study
·doi:10.1016/s2352-3026(23)00174-6

BackgroundThe MOMENTUM study met all key endpoints at week 24, demonstrating symptom, spleen, and anaemia benefits with momelotinib versus danazol in patients with myelofibrosis. In this updated analysis, we report duration of week 24 respo…

article 2023
Patient-reported Outcomes and Quality of Life in Anemic and Symptomatic Patients With Myelofibrosis: Results From the MOMENTUM Study
·doi:10.1097/hs9.0000000000000966

Myelofibrosis (MF) is a chronic myeloproliferative neoplasm that typically manifests with debilitating symptoms that progressively worsen, negatively impacting patients' quality of life. Fatigue is a multifactorial and burdensome MF-related…

article 2022
Epidural or intrathecal morphine for post-operative analgesia following laparoscopic endometriosis surgery
·doi:10.33545/26643766.2022.v5.i3a.358

Background: Endometriosis is the development of endometrial glands or stroma outside the uterine cavity, in the pelvis, ovaries, and fallopian tubes. Laproscopy is the most common method used in management of endometriosis and it also elimi…

article 2022
MPN-478 MOMENTUM: Phase 3 Randomized Study of Momelotinib (MMB) versus Danazol (DAN) in Symptomatic and Anemic Myelofibrosis (MF) Patients Previously Treated With a JAK Inhibitor
·doi:10.1016/s2152-2650(22)01463-x
article 2022
MPN-483 Thrombocytopenic Myelofibrosis (MF) Patients Previously Treated With a JAK Inhibitor in a Phase 3 Randomized Study of Momelotinib (MMB) versus Danazol (DAN) [MOMENTUM]
·doi:10.1016/s2152-2650(22)01464-1
article 2022
Poster: MPN-478 MOMENTUM: Phase 3 Randomized Study of Momelotinib (MMB) versus Danazol (DAN) in Symptomatic and Anemic Myelofibrosis (MF) Patients Previously Treated With a JAK Inhibitor
·doi:10.1016/s2152-2650(22)00950-8
article 2022
Poster: MPN-483 Thrombocytopenic Myelofibrosis (MF) Patients Previously Treated With a JAK Inhibitor in a Phase 3 Randomized Study of Momelotinib (MMB) versus Danazol (DAN) [MOMENTUM]
·doi:10.1016/s2152-2650(22)00951-x
article 2022
Thrombocytopenic myelofibrosis (MF) patients previously treated with a JAK inhibitor in a phase 3 randomized study of momelotinib (MMB) versus danazol (DAN) [MOMENTUM].
·doi:10.1200/jco.2022.40.16_suppl.7061

7061 Background: MMB, an oral JAK1/2 and ACVR1/ALK2 inhibitor, showed clinical activity on MF symptoms, RBC transfusion requirements (anemia), and spleen volume in the SIMPLIFY trials, including in MF patients (pts) with thrombocytopenia. M…

article 2017
Endometriosis: A Masquerade
·doi:10.14309/00000434-201710001-02497

KR is a 31 year-old woman with past medical history significant for an atrial septal defect who first presented in August 2016 with constant lower abdominal cramping with nausea, diarrhea, and vaginal bleeding during her usual menstrual cyc…