Simone Ferrero

Endometriosis is a chronic disease characterized by the growth of endometrial-like glands and stroma outside the uterine cavity. Nowadays, the exact etiology of endometriosis is unclear and the interaction between a variety of environmental…

First-line medical therapies for treating pain associated with endometriosis mainly consist in combined oral contraceptives and progestins. However, some women, having persistence of symptoms, may require further therapeutic options. Among …

KEYWORDS: Endometriosisestrogen biosynthesisAKR1C3steroid sulphatase17β-hydroxysteroid dehydrogenase 1aromatase inhibitors

OBJECTIVE: A systematic review was carried out of studies of women with endometriosis, to examine the evidence for efficacy of the use of hormonal contraception to improve disease-related pain and decrease postoperative risk of disease recu…

Background and objective: Previous studies did not draw a definitive conclusion about the influence of the role of deep endometriosis (DE) and ovarian endometrioma (OE) as risk factor for developing adverse perinatal outcomes in patients af…

In conclusion, a high number of new investigational drugs targeting specific biological mechanisms have recently been proposed for treatment of endometriosis. Although the use of new hormonal treatments, such as GnRH-antagonists, is being d…

The primary objective of this study was to assess the changes in the ultrasonographic characteristic of endometriosis in patients undergoing long-term follow-up. The secondary outcome of the study was to assess the long-term impact of hormo…

The primary objective of this study was to evaluate the changes in the volume of rectosigmoid endometriotic nodules during treatment with dienogest (DNG). The secondary aim of the study was to assess the changes in pain and intestinal sympt…

To investigate the performance of transvaginal hysterosalpingo-contrast-sonography (HyCoSy) in assessing tubal patency in women with endometriosis. This study was based on the retrospective analysis of a prospectively collected database of …

Circulating placental growth factor (PlGF) levels are increased in women with endometriosis when compared with controls, conversely decreased levels of PlFG have been reported in pregnant women developing pre-eclampsia. For this reason, end…

This study aims to compare the performance of bidimensional rectal-water contrast-transvaginal ultrasonography (2D-RWC-TVS) with 3D-RWC-TVS for investigating the presence and characteristics of rectosigmoid endometriosis. This prospective s…

Endometriosis is a chronic disease characterized by the presence of hormone-responsive endometriotic glands and stroma outside the uterus that affect at least 4% of reproductive age women (1). It may be asymptomatic, but it frequently cause…

The non-surgical diagnosis of endometriosis is still challenging for the clinician. Ultrasonography and magnetic resonance imaging can be used to diagnose ovarian endometriotic cysts and deep infiltrating endometriosis; but their performanc…

Adenomyosis is a gynecologic disorder characterized by the presence of ectopic endometrial tissue within the uterine myometrium. It can involve most of the myometrium (diffuse adenomyosis), it may be present only in a circumscribed part of …

This study aimed to investigate the efficacy of the etonogestrel (ENG)-releasing implant in treating patients with rectovaginal endometriosis. The study was based on the retrospective analysis of a prospectively collected database, includin…

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012

Endometriosis is a chronic benign disease that affects women of reproductive age. Medical therapy is often the first line of management for women with endometriosis in order to ameliorate symptoms or to prevent post-surgical disease recurre…