Lulu Ren

No ORCID on file · 8 papers in corpus
article 2026
The therapeutic potential of pirfenidone in alleviating fibrosis and restoring ovarian function in a novel ovarian endometriosis mouse model
Journal of translational medicine ·doi:10.1186/s12967-025-07648-z

BACKGROUND: Ovarian endometriosis (OEMs) is a primary cause of female infertility and is driven primarily by fibrosis, which disrupts the ovarian follicular microenvironment. Pirfenidone (PFD), an FDA-approved antifibrotic drug, holds promi…

article 2024
Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202302195r

Endometriosis (EMs)-related infertility commonly has decreased endometrial receptivity and normal decidualization is the basis for establishing and maintaining endometrial receptivity. However, the potential molecular regulatory mechanisms …

article 2021
Construction of Competing Endogenous RNA Networks Incorporating Transcription Factors to Reveal Differences in Granulosa Cells from Patients with Endometriosis
Genetic testing and molecular biomarkers ·doi:10.1089/gtmb.2020.0152

Purpose: This study was designed to reveal the molecular differences between granulosa cells (GCs) from patients with endometriosis and normal controls. Methods: RNA sequencing was performed on GCs from patients with EM-related infertility …

article 2020
Differential expression of microRNA in exosomes derived from endometrial stromal cells of women with endometriosis-associated infertility
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2020.04.010

Research questionWhat is the expression pattern of microRNA (miRNA) in exosomes isolated from eutopic endometrial stromal cells (EuESC) of women with endometriosis-associated infertility?DesignSmall RNA sequencing was conducted in exosomes …

preprint 2019
Construction of a ceRNA network combining transcription factors in eutopic endometrial tissue of tubal factor infertility and endometriosis-related infertility
·doi:10.21203/rs.2.19312/v1

Abstract Purpose Although tubal factor infertility (TFI) and endometriosis-related infertility all can result in female infertility, the pathogenesis of TFI and endometriosis-related infertility were different. The pathophysiologic mechanis…

article 2019
Lipoxin A4 Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPk Activation in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719119828115

Endometriosis is an inflammation-dependent gynecologic disorder. Increased cyclooxygenase-2 (COX-2) expression plays an important role in the development and progression of endometriosis. Lipoxin A4 (LXA4) is an endogenous anti-inflammation…

article 2018
High expression of ZEB1 in endometriosis and its role in 17β-estradiol-induced epithelial-mesenchymal transition.
International journal of clinical and experimental pathology

Endometriosis is an estrogen-dependent disease associated with pain and infertility. The objective of this study was to determine the expression of ZEB1 in endometriosis and its role in 17β-estradiol (E2)-induced epithelial-mesenchymal tran…

article 2018
Long non‐coding RNA AFAP1‐AS1 promoting epithelial‐mesenchymal transition of endometriosis is correlated with transcription factor ZEB1
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13074

PROBLEM: The role of the long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) in the etiology of endometriosis is unknown. METHOD OF STUDY: Expression of epithelial-mesenchymal transition (EMT) markers…