Chen R

BACKGROUND: Ovarian cancer is a lethal gynecological malignancy, with ~70% of patients diagnosed at advanced stages (5-year survival <30%) due to suboptimal early detection tools. Current modalities [e.g., carbohydrate antigen 125 (CA125), …

BACKGROUND: The relationship between gonadotropin-releasing hormone agonists (GnRH-as) and depression and suicide/self-injury (DASSI) remains controversial. This study aimed to investigate this potential association using data from the FDA …

PURPOSE: To characterize the clinical phenotypes of congenital genital tract malformations and evaluate their associations with endometriosis (EM) and fertility outcomes. PATIENTS AND METHODS: This retrospective cohort study analyzed 306 w…

BACKGROUND: Damage-associated molecular patterns (DAMPs) are endogenous molecules released or exposed during cellular stress, injury, or death. Initially characterized as danger signals that alert the immune system, DAMPs are now recognized…

STUDY QUESTION: Does adding vaginal estradiol to standard progesterone luteal phase support improve ongoing pregnancy rates in normal-responder IVF/ICSI patients undergoing GnRH antagonist cycles? SUMMARY ANSWER: The addition of vaginal es…

PURPOSE: To evaluate changes in immunoexpression of proteins involved in epigenetic regulation in the uterus in female ICR mice following neonatal exposure to tamoxifen. METHODS: Thirty-two neonatal mice were randomly assigned to 2 groups:…

Earlier examinations of how risk factors relate to endometriosis (EMT) have largely depended on observational designs, which arrived at conflicting conclusions. The present approach seeks to probe the causal association between 108 traits a…

BACKGROUND: Endometrial receptivity (ER) serves as a critical determinant for successful embryo implantation, yet its molecular complexity and limited clinical assessment methods pose significant challenges. Despite advancements in assisted…

The "gut microbiota-mitochondria axis" has become the core hub connecting the metabolism, immunity, and endocrine regulation of gynecological diseases. In this review, the hierarchical regulation mechanism of this axis is systematically com…

OBJECTIVE: To compare perioperative safety, efficiency and learning curves of MPLH, RASPH and SPLH, and analyze surgical disparities stratified by uterine volume. We adopted multivariable regression (primary adjusted analysis) and multinomi…

Endometriosis is a common gynecological disorder characterized by the ectopic growth of endometrium-like tissue outside the uterine cavity and is associated with pelvic pain, infertility, and reduced quality of life. Although several theori…

BACKGROUND: Spironolactone, a potassium-sparing diuretic, is commonly prescribed for conditions such as heart failure, hypertension, and hyperaldosteronism. This study aims to explore and analyze the safety profile of spironolactone by exam…

Current interventions for endometriosis mainly involve hormone therapies but have limited efficacy and unacceptable side effects due to the lack of selectivity to distinguish between endometriosis and endometrial tissues. Elucidating the mo…

OBJECTIVES: Endometriosis is a common condition among women, characterized by chronic pain and infertility, presenting significant challenges for clinicians. This study aims to identify potential druggable targets to offer new therapeutic a…

Pattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). They serve as essential links between the innate and adaptive …

STUDY OBJECTIVE: According to a four-level scale of endometriosis surgical complexity, the 2021 American Association of Gynecologic Laparoscopists (AAGL) endometriosis classification system was externally and prospectively validated. And we…

Polycystic ovary syndrome (PCOS) is an endocrine metabolic syndrome characterized by ovulation disorders, hyperandrogenemia, and polycystic ovaries, which seriously affect the psychological and physical health of childbearing women. N6-meth…

BACKGROUND: Hydroxyurea (HU) is an antitumor drug. However, HU exposure is associated with diminished ovarian reserve (DOR). Zi Chong granules, a Chinese Medicine, can protect against DOR, but little is known regarding its underlying mechan…

BACKGROUND: Cuproptosis is a novel copper-dependent mode of cell death that has recently been discovered. The relationship between Cuproptosis-related ncRNAs and breast cancer subtypes, however, remains to be studied. METHODS: The aim of t…

(1) Background: Diabetes mellitus (DM) induces oxidative stress and inflammation with negative effect on pregnancy outcomes. This study aimed to determine whether DM increases the risk of pregnancy loss and to identify other potential risk …

Melatonin, as an endocrine neurotransmitter, can promote the development of the ovary. Meanwhile, it also has protective effect on the ovary as an antioxidant. Thyroid hormone (TH) is essential for normal human reproductive function. Many s…

BACKGROUND: The heterogeneity and dynamic changes of endometrial cells have a significant impact on health as they determine the normal function of the endometrium during the menstrual cycle. Dysfunction of the endometrium can lead to the o…

Fetal growth restriction (FGR) increases the risk of short-term and long-term complications. Widespread N6-methyladenosine (m6A) modifications on mRNAs have been found to be involved in various biological processes. However, the role of m6A…

BACKGROUND: Historically, the clinical characteristics and treatment pathways for patients with uterine fibroids and heavy menstrual bleeding have differed between White and Black women. OBJECTIVE: To provide a contemporary comparison of p…

Secondary dysmenorrhea is a pain associated with disease such as endometriosis, pelvic inflammatory disease, leiomyomas, and interstitial cystitis. Treatment of secondary dysmenorrhea always focuses on the causative pelvic pathology or medi…