Yan Li

BACKGROUND: Intrauterine platelet-rich plasma (PRP) has been proposed as an adjunctive intervention for patients with thin endometrium or recurrent implantation failure before embryo transfer, but evidence remains limited by heterogeneous p…

BACKGROUND: Studies have shown that dysregulation of the gut microbiota (GM) plays a crucial role in the development of endometriosis (EMs). Study aimed to investigate the potential of protective GM metabolites in treating EM through networ…

This study investigated the potential role of gut microbiota metabolites in endometriosis using network pharmacology and Mendelian randomization. Key biomarker genes related to protective gut microbial metabolites were identified and analyz…

This study investigated the potential role of gut microbiota metabolites in endometriosis using network pharmacology and Mendelian randomization. Key biomarker genes related to protective gut microbial metabolites were identified and analyz…

Human endometrial receptivity is a critical determinant of pregnancy success; however, in vivo studies of its features and regulation are particularly challenging due to ethical restrictions. Recently, the development of human endometrial a…

OBJECTIVES: To analyze the association between primary infertility and infertility type with the age of natural menopause. METHODS: This is a retrospective cohort study reviewing a subset of women from the Mayo Primary Infertility Cohort (…

BACKGROUND: Endometriosis (EMS) is an estrogen-dependent chronic inflammatory disorder for which metabolic reprogramming has emerged as a central pathological feature. Driven by genetic, epigenetic, and microenvironmental stressors, ectopic…

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

Hysterectomy is the regimen of choice for benign gynecologic diseases, including uterine myoma, adenomyosis, endometriosis, and genital prolapse. Surgeons choose hysterectomy methods based on clinical situations or patients' preferences. Ev…

OBJECTIVE: To assess the safety and efficacy of percutaneous intrauterine hydrodissection as a protective technique during microwave ablation (MWA) of uterine fibroids adjacent to the endometrium. MATERIALS AND METHODS: A retrospective ana…

OBJECTIVES: The aim of this study was to examine SEMA3C expression in endometriosis (EMs) and its relationship with ferroptosis in human endometrial stromal cells (HESCs). DESIGN: This experimental study used patient tissue samples and in …

Hysterectomy is a frequent gynecological surgical technique. With the extensive application of robot-assisted laparoscopic surgery, the feasibility of robot-assisted transvaginal natural orifice translumenal endoscopic surgery (v-NOTES) has…

Objectives: To examine SEMA3C expression in endometriosis (EMs) and its relationship with ferroptosis in human endometrial stromal cells (HESCs).Design: Experimental study using patient tissue samples and in vitro gain- and loss-of-function…

Objectives: To examine SEMA3C expression in endometriosis (EMs) and its relationship with ferroptosis in human endometrial stromal cells (HESCs).Design: Experimental study using patient tissue samples and in vitro gain- and loss-of-function…

PURPOSE: To explore the impact of seasonal variations on the risks of hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) in women who undergo in vitro fertilization (IVF) treatment. METHODS: We retrospectivel…

Women's reproductive health plays a pivotal role in both longevity and the aging process. We conduct Mendelian randomization (MR) and observational analyses to investigate these relationships. Univariate MR analyses reveal that older age at…

This case series explores the diagnostic overlap between OHVIRA syndrome (obstructed hemivagina and ipsilateral renal anomaly) and Gartner duct cyst (GDC) with ipsilateral renal dysplasia in two prepubertal girls. Both cases exhibited simil…

IN BRIEF: There is no ideal animal model of adenomyosis, which reflects the imperfect understanding of complex human pathogenesis. In this study, we successfully induced adenomyosis in a mouse model via sharp-blunt trauma, which more closel…

STUDY QUESTION: What are the impacts of different male infertility factors on embryological, cumulative pregnancy and neonatal outcomes of IVF/ICSI cycles? SUMMARY ANSWER: Some severe male infertility factors, i.e. severe oligoasthenozoosp…

OBJECTIVES: Whether diverse metabolic statuses within a similar body mass index (BMI) category associate with different in vitro fertilization (IVF) outcomes. DESIGN: A retrospective cohort study. SETTING: Wenzhou, Zhengjiang Province, Ch…

BACKGROUNDS: The study was designed to analyze early pregnancy loss rates in first-time fresh embryo transfer cycles in low prognosis patients according to the POSEIDON criteria. METHODS: This was a retrospective cohort study, including pa…

BACKGROUND: Nei Like DNA Glycosylase 2 (NEIL2) is strongly associated with the risk of Cervical cancer (CC), but the mechanism is not yet clear. Therefore, the aim of this study was to explore the potential mechanisms of NEIL2 as a novel pr…

Endometriosis (EM) is a common and challenging condition of reproductive-aged women and its pathogenesis is associated with endometrial stromal cells (ESCs). This study aimed to explore the role of FOXC1 in invasion and migration of ectopic…

Abnormal apoptosis both maintains endometrial cell growth and induces endometrial pathogenesis. The etiology of endometriosis is unclear and no treatment is curative. Therefore, the aim herein was to identify genes involved in the pathogene…

BACKGROUND: Emerging evidence suggests that aberrantly expressed microRNAs (miRNAs) participate in endometriosis pathogenesis. miR-1229-5p participates in the pathogenesis of several disease, but its precise role and mechanism in endometrio…