Lydon JP

No ORCID on file · 57 papers in corpus · active 2004-2025

Study types

  • article 12
  • other 6
  • review 5
  • preprint 1

Condition tags

  • endometriosis 21
  • infertility 16
  • chronic_pelvic_pain 1
  • adenomyosis 1
2010
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action.
Journal of oncology ·doi:10.1155/2010/139087

Endometrial cancer is the most common gynecological cancer. Estrogen-dependent endometrioid carcinoma is the most common type of endometrial cancer, and alterations in the expression of PTEN and K-ras have been associated with this disease.…

article 2009
ERBB Receptor Feedback Inhibitor 1 Regulation of Estrogen Receptor Activity Is Critical for Uterine Implantation in Mice1
Biology of reproduction ·doi:10.1095/biolreprod.109.081307

Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. E2 acts to stimulate the proliferation of uterine epithelial cells, while P4 action inhibits E2-mediated proliferation of the epithelium. P4 thro…

2009
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.0903632106

Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. An imbalance caused by increased E2 action and/or decreased P4 action can result in abnormal endometrial proliferation and, ultimately, endometri…

review 2008
In vivo analysis of progesterone receptor action in the uterus during embryo implantation
Seminars in cell & developmental biology ·doi:10.1016/j.semcdb.2007.12.001

In order for a successful pregnancy to occur, the embryo must attach to the luminal epithelial cells and invade into the stroma. Then, the surrounding stromal cells need to undergo decidualization in order to establish the vasculature neces…

other 2007
COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity
PLoS genetics ·doi:10.1371/journal.pgen.0030102

Progesterone and estrogen are critical regulators of uterine receptivity. To facilitate uterine remodeling for embryo attachment, estrogen activity in the uterine epithelia is attenuated by progesterone; however, the molecular mechanism by …

2007
Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human.
Nuclear receptor signaling ·doi:10.1621/nrs.05011

Although the importance of the progesterone receptor (PR) to female reproductive and mammary gland biology is firmly established, the coregulators selectively co-opted by PR in these systems have not been clearly delineated. A selective gen…

article 2004
Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis
Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.01.048

ObjectiveTo determine the role of P and its nuclear receptor PR in the growth of ectopic uterine tissue of mice with or without a disrupted PR gene.DesignAnimal study.SettingAcademic medical center.Animal(s)Female wild-type (WT) and transge…