Virginia Manzi

• Adenomyosis shows a strong association with heavy menstrual bleeding. • Endometriosis is linked to more severe pain-related symptoms than adenomyosis. • Dyspareunia is common in both conditions and lacks discriminatory value. • Coexistenc…

• Endometriosis and fibromyalgia frequently co-occur, even though in more than two-thirds of cases, the diagnosis of endometriosis preceded that of fibromyalgia. • Patients with endometriosis and fibromyalgia exhibit distinct clinical chara…

PROBLEM: Immunological abnormalities are well recognized in the pathogenesis of endometriosis and the co-existence of endometriosis with inflammatory bowel disease (IBD) and celiac disease (CD), along with other systemic immune disorders, i…

BACKGROUND: Adenomyosis is a uterine disorder causing menstruation-related symptoms such as dysmenorrhea, heavy menstrual bleeding (HMB) and dyspareunia. A long-term management of the disease is required. Hormonal drugs are the most used, i…

RESEARCH QUESTION: How do comorbidities and their prevalence differ between patients with adenomyosis alone and patients with both adenomyosis and endometriosis? DESIGN: A prospective observational study compared the presence of comorbidit…

BACKGROUND: Dienogest (DNG) improves endometriosis-associated pain (EAP) and patients' quality of life; however, the modern cornerstone of the management of endometriosis is the long-term adherence of the patient to medical treatment. OBJEC…

Endometriosis, a chronic gynecological disease, affects millions of women worldwide, significantly impacting their quality of life. A reported delay, ranging from 4 to 12 years, exists between the onset of symptoms and the formal diagnosis.…