Chen L

Qiaomei Yang,1,* Jingxuan Hong,2,3,* Xinye Zheng,1,* Xianhua Liu,4 Hao Lin,1 Li Chen,1 Fuchun Zhong,5 Qianhui Zhang,1 Junying Jiang,1 PengMing Sun1 1Department of Gynecology, Fujian Maternity and Child Health Hospital, College o…

BACKGROUND: Adenomyosis is a chronic inflammatory gynecological disorder closely linked with diminished fertility potential that poses significant challenges in pharmacological management. Salvia miltiorrhiza (Danshen, DS), a traditional Ch…

PURPOSE: To study the global, regional and national burden and trend of primary and secondary infertility, by sex and sociodemographic index (SDI), over the period 1990-2021. METHODS: Data on the prevalence and disability-adjusted life yea…

BACKGROUND: Surgery is the primary treatment for Endometrial Stromal Sarcoma (ESS), however, a substantial proportion of patients with ESS experience recurrence or metastasis. Currently, surgery and local ablation are the main treatments fo…

BACKGROUND: Metabolic dysregulation plays a critical role in polycystic ovary syndrome (PCOS), yet the involvement of energy metabolism-related genes (ERGs) remains incompletely understood. This study employs integrative bioinformatics and …

Adenomyosis (AM) is recognized as a complex gynecological and endocrine disorder that contributes to infertility and elevates the risk of pregnancy complications; however, its underlying genetic basis remains unidentified. This study aimed …

STUDY QUESTION: Can a panel of plasma protein biomarkers be identified to accurately and specifically diagnose endometriosis? SUMMARY ANSWER: A novel panel of 10 plasma protein biomarkers was identified and validated, demonstrating strong …

Endometriosis is a common disease among women of childbearing age, and endoplasmic reticulum stress (ERS), a response involved in regulating protein homeostasis, has been linked to its pathogenesis. To identify ERS-related hub genes, this s…

Adenomyosis (AM) is characterized as a chronic and progressive disorder with limited therapeutic strategies available. Myometrial fibrosis is a prominent pathological feature of AM, yet the underlying molecular mechanisms remain elusive. Th…

BACKGROUND: Intra-abdominal hemorrhage (IAH) is a rare but potentially life-threatening complication of ultrasound-guided transvanginal oocyte pick up (OPU). Despite the widespread use of OPU in assisted reproductive technology, minor hemor…

OBJECTIVE: Recurrent spontaneous abortion (RSA) is a major pregnancy complication with unclear pathogenesis. This study aims to investigate the role of miR-20b-5p and its downstream target HIF-1α in trophoblast function and RSA pathogenesis…

Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications. However, the role of protein palmitoylation in oocyte aging ha…

The substantial apprehension facing young cancer patients revolves around the onset of chemotherapy-induced premature ovarian failure (POF), primarily linked to damage inflicted upon granulosa cells (GCs). The inquiry delves into the protec…

Mitochondria, the powerhouse of the cell, orchestrate a plethora of critical functions, including energy production, metabolic regulation, programmed cell death, and signal transduction. Their pivotal role in the pathogenesis of numerous di…

Endometriosis significantly impacts women's health and fertility, with cell aging playing a crucial role in its development. This study utilized a multi-omic summary Mendelian randomization (SMR) analysis, integrating genome-wide associatio…

OBJECTIVE: We aimed to analyze the correlation between the neutrophil-to-lymphocyte ratio (NLR), and the treatment outcomes for infertile women after in vitro fertilization (IVF) using embryo transfer technology. METHODS: This retrospectiv…

Patients with systemic lupus erythematosus (SLE) often have decreased fertility. Gene translation is crucial to oocyte meiosis and development. However, it remains unclear how SLE affects this process. Here, we used single-cell transcriptom…

BACKGROUND: Poor ovarian response (POR) is a pathological condition characterized by inadequate ovarian response to gonadotropin stimulation in patients undergoing in vitro fertilization and embryo transfer. It represents a primary cause of…

Postpartum uterine necrosis is a rare and serious complication. The uterine tissue becomes devascularized and then causes endometrial necrosis and even myometrial necrosis, usually combing with uterine infection. To clear the infection, hys…

BACKGROUND: Infertility is a growing global challenge that affects millions of people, and various factors influence female reproductive health. This study examined the association between inflammatory indicators, nutritional status, metabo…

BACKGROUND: Pelvic abscesses represent acute gynecological emergencies requiring timely intervention. This study evaluated prognostic predictors and treatment modalities in patients with pelvic abscesses. METHODS: We conducted a retrospect…

Osteopontin (OPN) is an extracellular matrix protein secreted by various types of cells, and serves multiple physiological roles such as modulating bone cell maturation, immune responses, tissue repair and regeneration. Aberrant OPN express…

OBJECTIVES: Adenomyosis (AM) is a chronic disorder that significantly impacts women's health and quality of life worldwide, particularly by causing progressive impairment in fertility. This study aimed to summarize and visualize the literat…

RATIONALE: Sepsis following hysteroscopy is an rare complication, with current evidence suggesting that routine prophylactic antibiotic administration may not be warranted. However, this does not imply that we should disregard vigilance reg…

Abstract The characteristic of endometriosis is that the endometrial tissue grows in non-endometrial parts such as the pelvis and ovaries, leading to infertility and chronic pain. However, its pathophysiology is still unclear. Using high-p…