Chen J

Despite intensive development, P2X7 modulators have struggled in translation due to human genetic variability and species-dependent drug responses. Here, we identify PSFL1191, a portal-of-central-pocket (PCP)-site inhibitor selective for hu…

STUDY QUESTION: What molecular mechanisms underlie the decline in ovarian reserve as the number and quality of oocytes decrease in patients with ovarian endometriomas (OEM)? SUMMARY ANSWER: Elevated expression of the let-7 micro(mi)RNAs in…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. Despite its prevalence, the underlying mechanisms contributing to the pathogenesi…

Abstract Objective To analyse and summarise the clinical characteristics, diagnosis, treatment and prognostic features of abdominal wall endometriosis. Methods A retrospective analysis of patients with abdominal wall endometriosis who atte…

OBJECTIVE: To establish a rat model of pharmacological ovariectomy by GnRH-a injection and to preliminarily investigate the reproductive endocrine effects of Xiangshao granules on pharmacologically ovariectomized rats. METHODS: A rat model …

We evaluated the impact of adenomyosis and ovarian endometriosis on ovarian reserve function through transvaginal three-dimensional ultrasound and anti-mullerian hormone testing. A total of 150 female patients who were admitted to our hospi…

BackgroundThe use of antioxidant-rich foods to treat female infertility has received significant attention in recent years. The aim of this study was to investigate the potential correlation between the composite dietary antioxidant index (…

BackgroundLow-dose aspirin is one of the widely used adjuvants in assisted reproductive technologies with the hope of improving the live birth rate. However, the studies regarding its effects are conflicting. The study aimed to investigate …

Abstract Objective: Previous observational research has indicated an association between plasma selectin family members and endometriosis, and our objective was to investigate the causal association between selectins and endometriosis. Met…

PurposeThis study aimed to investigate the clinical and pathological characteristics, treatment strategies, and prognosis of cervical clear cell carcinoma (CCCC) in patients not exposed to diethylstilbestrol in utero.MethodsThe patients dia…

BackgroundThe low live birth rate and difficult decision-making of the in vitro fertilization (IVF) treatment regimen bring great trouble to patients and clinicians. Based on the retrospective clinical data of patients undergoing the IVF cy…

Abstract Objective Screen the relevant diagnostic indicators of endometriosis, build a diagnostic model and verify it, so as to provide a scientific basis for diagnosis and differentiation.zig. Method(s) A total of 625 patients with patholo…

•The reference intervals calculated using RefineR, Kosmic, TMC, and non-parametric methods are similar.•TMC algorithm is more robust, demonstrates a high pass rate among the four methods and has the ability to automatically isolate outliers…

Ovarian cancer (OC) represents the most prevalent malignancy of the female reproductive system. Its distinguishing features include a high aggressiveness, substantial morbidity and mortality, and a lack of apparent symptoms, which collectiv…

Telocytes (TCs) have been identified in various animals. However, information on TCs in the embryos is still very limited. In this work, the developing skin of the silky fowl was sampled for TCs identification by histology, immunohistochemi…

AIM: We aimed to compare the diagnostic performance of transvaginal sonography (TVS) versus magnetic resonance imaging (MRI) in identifying deep infiltrating endometriosis (DIE) in the rectovaginal septum (RVS) of affected patients. MATERI…

PurposeDecreased ovarian reserve function is mainly characterized by female endocrine disorders and fertility decline. Follicular fluid (FF) exosomal microRNAs (miRNAs) have been shown to regulate the function of granulosa cells (GCs). The …

Ovarian endometrioma (OE), also known as "chocolate cysts," is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, lea…

INTRODUCTION: Endometriosis is a heritable, complex chronic inflammatory disease, for which much of the causal pathogenic mechanism remain unknown.Despite the high prevalence of ovarian chocolate cyst, its origin is still under debate. MET…

PurposeTo evaluate the contribution of the cleavage stage morphological parameters to the prediction of blastocyst transfer outcomes.MethodsA retrospective study was conducted on 8383 single-blastocyst transfer cycles including 2246 fresh a…

BackgroundThe purpose of this study was to investigate the effects of intravenous anesthetic drugs on fertilization rate in subjects receiving oocyte retrieval by assisted reproduction technology (ART).MethodsA retrospective cohort study wa…

ObjectivesTo explore the relationship between different types of physical activity and female infertility.MethodsThis study analyzed data from 2,796 female participants aged 18-44 years in the United States, obtained from the National Healt…

Structured Abstract Introduction Adenomyosis is an under-recognised condition in which definitive diagnosis is only possible via histology after hysterectomy, an unacceptable option for those wishing to preserve fertility. Recent cellular/m…

BackgroundLung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen dependence, suggest that …

Metamorphosis control is pivotal in preventing the outbreak of jellyfish, and it is often studied using common model organisms. The widespread use of the ultraviolet blocking agent homosalate in cosmetics poses a threat to marine ecosystems…