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BACKGROUND: Smoking and alcohol consumption have been consistently associated with adverse female reproductive outcomes; however, whether these associations reflect causal effects or are mediated by specific circulating metabolites remains …

INTRODUCTION: Female diseases pose significant challenges in South Asia and Sub-Saharan Africa, particularly among adolescent girls and young women, who often receive insufficient attention. OBJECTIVES: To report patterns and trends of fem…

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profi…

BACKGROUND: Assisted reproductive technologies (ART) have been proven to be associated with the increased risk of pregnancy complications such as gestational hypertension and neonatal disorders, which may have negative effects on offspring'…

OBJECTIVE: This study aims to evaluate and compare the clinical effectiveness of endovascular reintervention vs conservative medical therapy in patients with persistent or recurrent venous-origin chronic pelvic pain (CPP) after initial endo…

BACKGROUND: Over 2.5 million cycles in vitro fertilization (IVF) are conducted annually, and numbers are expected to rise with the aging population. The controlled ovarian stimulation (COS) process, key to IVF success, is inherently complex…

OBJECTIVES: This study aims to evaluate the safety and efficacy of ovarian vein embolization combined with polidocanol sclerotherapy for Venous-origin chronic pelvic pain (VO-CPP) and to elucidate potential risk factors affecting prognosis.…

Extracellular vesicles (EVs) in the mammalian oviduct constitute a key maternal regulatory system that maintains redox balance during early embryogenesis, yet their molecular cargo and functional relevance in human embryos remain poorly def…

BACKGROUND: Endometriosis (EMs) is one of the most common gynecologic diseases, and the roles of ferroptosis in EMs have not been fully clarified. The induction of ferroptosis has been demonstrated to inhibit the growth of ectopic lesions i…

This study aimed to investigate how levels of serum follicle-stimulating hormone (FSH) on Day 7 of ovarian stimulation are related to the number of oocytes retrieved, and identify any cutoff or threshold point in protocols using gonadotropi…

Adenomyosis (AM), an estrogen‑dependent chronic inflammatory disease with a rising incidence, has emerged as a major cause of infertility and reduced clinical pregnancy rates in reproductive‑aged women, severely impairing reproductive healt…

Growing evidence highlights the gut, reproductive tract, and endometrial microbiota as important functional contributors in the pathogenesis of endometriosis (EM). Studies have revealed a characteristic microbial imbalance in patients with …

PURPOSE: Cancer treatments can deplete the ovarian follicle reserve causing infertility and early menopause, with subsequent decline in cardiovascular, cognitive, and overall health. Medical measures to prevent this chemotherapy-induced ova…

Sleep disorders and deficiencies can up-regulate pro-inflammatory mediators, but their potential adverse impact on ovarian function remains not fully understood. In this study, we investigated the immunoregulatory mechanisms underlying slee…

Adenomyosis is a common and difficult disease in gynecology. Its main clinical manifestations include uterine hypertrophy, excessive menstruation, pelvic pain and infertility, which have a serious impact on women's health. Seriously affects…

INTRODUCTION: Ovarian cancer (OC) and endometrial cancer (EC) represent two prevalent tumors within the female reproductive system, characterized by high incidence rates. Nonetheless, the clinicopathological features of synchronous endometr…

OBJECTIVE: To investigate the correlation between preoperative pathologic characteristics and the risk of postoperative recurrence in endometriosis (EMs) patients, and to develop a clinical predictive model. METHODS: A retrospective analys…

UNLABELLED: Vulvar lichen sclerosus (VLS) is a chronic skin condition affecting the vulva, causing significant discomfort, but its etiology in prepubertal girls remains poorly understood. VLS presents with itching, irritation, and pain. Rec…

Spatial transcriptomics enables in situ molecular profiling, allowing to measure the cellular transcriptional output within the tissue. As the tissue architecture is conserved, spatial domains with specific transcriptional patterns can be i…

OBJECTIVE: To evaluate the pregnancy and perinatal outcomes of different phenotypes of polycystic ovary syndrome (PCOS) patients during the frozen embryo transfer (FET) cycles. Additionally, to analyze the T cell balance in the endometrium …

Endometrial dysfunction underlies many common gynecologic disorders, such as endometriosis, endometrial cancer, intrauterine adhesions, and endometritis, which affect many women around the world. Extracellular vesicles play an important rol…

Diseases of the female reproductive system are prevalent. These conditions often have a high proportion of asymptomatic patients and prolonged treatment durations. Estrogen, a crucial steroid hormone, plays a central role in most diseases o…

BACKGROUND: Programmed protocols are most commonly chosen as endometrial preparation for women with polycystic ovarian syndrome (PCOS) undergoing frozen-thawed embryo transfer (FET) cycles. However, the efficacy of gonadotropin-releasing ho…