Shimeng Liu

No ORCID on file · 4 papers in corpus · active 2019-2023

Study types

  • article 2
  • review 1

Condition tags

  • endometriosis 1
  • chronic_pelvic_pain 1
  • infertility 1
article 2023
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas
·doi:10.1172/jci.insight.171305

Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiom…

article 2022
Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status
·doi:10.1007/s43032-022-00852-y

Uterine leiomyomas (fibroids) are common benign tumors in women. The tryptophan metabolism through the kynurenine pathway plays important roles in tumorigenesis in general. Leiomyomas expressing mutated mediator complex subunit 12 (mut-MED1…

2021
Job Preferences for Social Medicine and Health care Management PhD Students in China: A Discrete Choice Experiment
·doi:10.21203/rs.3.rs-146018/v1
review 2019
Endometriosis
Endocrine reviews ·doi:10.1210/er.2018-00242

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into t…