Robert L. Barbieri

lab-animal 1980

Danazol inhibits human adrenal 21-and 11 beta-hydroxylation in vitro

Steroids ·doi:10.1016/0039-128x(80)90038-0

The effects of danazol on steroidogenesis in vitro in the 16-20 week old human fetal adrenal were examined by studying: 1) danazol binding to adrenal microsomal and mitochondrial cytochrome P-450, and 2) enzyme kinetics of danazol inhibitio…

other 1980

Inhibition of adrenal steroidogenesis by danazol in vivo

Fertility and sterility ·doi:10.1016/s0015-0282(16)44657-1

lab-animal 1979

Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity

Fertility and sterility ·doi:10.1016/s0015-0282(16)43820-3

Danazol was found to possess androgenic and glucocorticoid activity in rat bioassays. In contrast, danazol displayed no significant estrogenic activity. In support of these findings, danazol bound to the 8 S androgen receptor of rat prostat…

lab-animal 1978

Pituitary gonadotropin responsiveness with danazol

Fertility and sterility ·doi:10.1016/s0015-0282(16)43336-4

Danazol (17alpha-pregn-4-en-20-yno-[2,3-d]isoxazol-17-ol) was administered daily for 4 days to castrated female rats. As previously demonstrated, danazol lowered serum levels of luteinizing hormone (LH) in an apparent dose-dependent fashion…

lab-animal 1977

Danazol Inhibits Steroidogenesis

·doi:10.1016/s0015-0282(16)42732-9

Danazol was found to inhibit multiple enzymes of steroidogenesis directly in the pregnant mare serum (PMS)-treated hamster ovary and the rat testis and adrenal in vitro. In the PMS-treated hamster ovary, danazol inhibited 17alpha-hydroxylas…

lab-animal 1977

Danazol inhibits steroidogenesis in the rat testis in vitro

Endocrinology ·doi:10.1210/endo-101-6-1676

The effects of danazol on steroidogenesis in vitro in the rat testis were examined by studying: 1) androgen synthesis in rat Leydig cells cultured with danazol, 2) danazol binding to rat testis microsomal cytochrome P-450, and 3) enzyme kin…