Patrick G Groothuis
No ORCID on file
· 55 papers in corpus
· active 1998-2025
Study types
- article 36
- dataset 12
- review 5
- other 2
Condition tags
- endometriosis 45
- mesh:D004715 25
- infertility 3
- adenomyosis 3
- die_deep_infiltrating 2
- bowel_endometriosis 1
Top journals
Frequent coauthors
article
2025
Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent models of endometriosis have been developed to explore multiple aspects of this poorly understood …
review
2025
The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disease pathogenesis using human cells. Three-dimensional models, particularly organoid systems, hav…
review
2025
Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amongst models and behavioural measures, in addition to inconsistent reporting, might limit the ove…
article
2022
OPINION article Front. Reprod. Health, 11 January 2022Sec. Gynecology Volume 3 - 2021 | https://doi.org/10.3389/frph.2021.809366
article
2019
Chronic pain and subfertility are the main symptoms of concern in women with endometriosis. In order to find new therapeutic options to suppress the pain, translational animal models are indispensable. We have developed a new automated, exp…
article
2018
review
2018
BACKGROUND: The drug research and development (R&D) for endometriosis/adenomyosis has been painfully slow. Most completed clinical trials on endometriosis did not publish their results, and presumably failed. While few published trials did …
article
2017
article
2012
other
2011
Angiogenesis is essential to restore the supply of oxygen and nutrients to the developing endometriotic lesions. The revascularization of the endometrial tissue is the result of complex interactions between the shed menstrual tissue arrivin…
other
2011
OBJECTIVE: To determine [1] expression levels of both DNA methyltransferases (DNMTs) and methyl-CpG-binding domain proteins (MBDs) in human endometrium throughout the menstrual cycle and in eutopic and ectopic endometrium of patients with e…
dataset
2011
dataset
2011
BACKGROUND: Endometriosis is an estrogen-dependent disease causing pelvic pain and infertility in 10% of reproductive-aged women. Despite a long history of the disease the pathogenesis of endometriosis is poorly understood. It is known that…
dataset
2010
dataset
2010
article
2010
article
2010
dataset
2009
dataset
2009
dataset
2009
CONTEXT: Endometriosis is a common condition associated with infertility and pelvic pain in women. Recent in vitro studies have shown that statins decrease proliferation of endometrial stroma (ES) and inhibit angiogenesis.OBJECTIVE: The aim…
article
2009
Context: substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a source of 17β-estradiol. However, whether these differences result in a net incre…
review
2008
It is widely known that angiogenesis plays a key role in endometriotic lesion formation and development. Antiangiogenic treatments aimed at inhibiting new vessel formation have proven efficient in experimental models. However, as antiangiog…
dataset
2008
article
2008
BACKGROUND: In this study, we characterized the fibromuscular (FM) tissue, typical of deeply infiltrating endometriosis, investigated which cells are responsible for the FM reaction and evaluated whether transforming growth factor-beta (TGF…
article
2008
CONTEXT: substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a source of 17beta-estradiol. However, whether these differences result in a net in…