Radke MR

No ORCID on file · 3 papers in corpus · active 2020-2024
2024
Gynecologic Oncology ·doi:10.1016/j.ygyno.2024.07.690

BackgroundIndividuals with germline BRCA1 and BRCA2 pathogenic variants (BRCA carriers) are at high risk of developing high grade serous ovarian carcinoma (HGSC). HGSC is predominantly driven by TP53 mutations, but mutations in this gene ar…

2022
Cancer research communications ·doi:10.1158/2767-9764.crc-22-0314

Current screening methods for ovarian cancer (OC) have failed to demonstrate a significant reduction in mortality. Uterine lavage combined with TP53 ultra-deep sequencing for the detection of disseminated OC cells has emerged as a promising…

2020
Gynecologic Oncology ·doi:10.1016/j.ygyno.2019.11.124

ObjectivePap tests hold promise as a molecular diagnostic for serous ovarian cancer, but previous studies reported limited sensitivity. Furthermore, the presence of somatic mutations in normal tissue is increasingly recognized as a challeng…