Nachmanson D

No ORCID on file · 2 papers in corpus · active 2019-2020
2020
Characterization of TP53 mutations in Pap test DNA of women with and without serous ovarian carcinoma.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2019.11.124

ObjectivePap tests hold promise as a molecular diagnostic for serous ovarian cancer, but previous studies reported limited sensitivity. Furthermore, the presence of somatic mutations in normal tissue is increasingly recognized as a challeng…

2019
Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan.
Cell reports ·doi:10.1016/j.celrep.2019.05.109

High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally invasive body fluid samples. We demonstrate 80% sensitivity for ovarian …