Itoh M

2025

High-Throughput Drug Screening of Clear Cell Ovarian Cancer Organoids Reveals Vulnerability to Proteasome Inhibitors and Dinaciclib and Identifies AGR2 as a Therapeutic Target.

Cancer research communications ·doi:10.1158/2767-9764.crc-25-0024

There are currently no effective treatments available for clear cell ovarian cancer (CCC). In this study, we aimed to identify effective drugs for CCC through high-throughput drug screening (HTDS) using ovarian cancer organoids and determin…

2024

A rare case of synchronous bilateral ovarian cancer with combined clear cell and mucinous carcinomas and brain metastases.

International cancer conference journal ·doi:10.1007/s13691-024-00686-2

Although ovarian cancer is generally unilateral, a few cases of bilateral ovarian cancer have been reported, most of which originate from metastases of unilateral ovarian cancer. However, synchronous primary bilateral ovarian cancer (SBOC),…

2020

Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.

Scientific reports ·doi:10.1038/s41598-020-69488-9

The use of primary patient-derived organoids for drug sensitivity and resistance testing could play an important role in precision cancer medicine. We developed expandable ovarian cancer organoids in < 3 weeks; these organoids captured the …

2017

Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis.

Scientific reports ·doi:10.1038/s41598-017-14418-5

For endometrial cancer patients, lymphadenectomy is recommended to exclude rarely metastasized cancer cells. This procedure is performed even in patients with low risk of recurrence despite the risk of complications such as lymphedema. A me…

2013

Cadmium exposure increases susceptibility to testicular autoimmunity in mice.

Journal of applied toxicology : JAT ·doi:10.1002/jat.2713

Cadmium, one of various environmental toxicants, is known to suppress systemic immunity and to injure the testicular capillary endothelia with resultant necrosis of testicular tissues in mice and rats treated with high doses. Recently, it a…

article 2009

[Catamenial pneumothorax with breast cancer treated successfully by goserelin acetate].

Kyobu geka. The Japanese journal of thoracic surgery

A 47-year-old woman with 4 episodes of right pneumothorax related to onset of menstruation was reported. A month ago, she was undergone breast conserving resection for breast cancer. She had recurrent right pneumothorax a month later and op…

2006

Reduction of perifollicular arterial blood flow resistance after hCG administration is a good indicator of the recovery of mature oocytes in ART treatment.

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-006-9087-4

PurposeTo demonstrate our hypothesis that a correlation exists between oocyte maturity and a decrease in intraovarian blood flow resistance in assisted reproductive technology (ART) treatment cycles, oocyte maturity and total antioxidant st…

article 1998

Ovarian abscess caused byPeptostreptococcus magnus following transvaginal ultrasound-guided aspiration of ovarian endometrioma and fixation with pure ethanol

Infectious diseases in obstetrics and gynecology ·doi:10.1002/(sici)1098-0997(1998)6:2<66::aid-idog7>3.0.co;2-5

BACKGROUND: Transvaginal ultrasound-guided aspiration of ovarian endometrioma has been applied and emphasized as a safe and simple procedure. CASE: Two 27-year-old infertile women, both gravida 0, para 0, underwent medical follow-up examina…

article 1991

[Endosalpingosis in the pelvic peritoneum and pelvic lymph nodes].

Nihon Sanka Fujinka Gakkai zasshi

The pelvic peritoneum with macroscopic findings characteristic of endometriosis was biopsied in 18 cases at conservative surgery for endometriosis and examined. Pelvic lymph nodes removed in 76 cases at radical surgery for uterine cervical,…

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