Chen H

Pyroptosis is an inflammatory form of cell death involving caspase-1 or caspase-4/5/11, initiated by inflammasomes or cytoplasmic endotoxins as part of the immune defense. It is specifically characterized by Gasdermin-mediated pore formatio…

BackgroundThe composite dietary antioxidant index (CDAI) reflects dietary antioxidant intake. Preliminary studies indicate that higher CDAI levels are associated with a lower prevalence of female infertility. However, the underlying mechani…

Inflammatory bowel disease (IBD) is a systemic condition with multifactorial origins. Mitochondria and ferroptosis have been implicated in the disease, but their potential interaction in IBD remains unclear. Therefore, investigating the rel…

BackgroundHigh rates of infertility and pregnancy complications in patients with intrauterine adhesion (IUA) even after surgical repair may be associated with poor endometrial receptivity (ER). In our previous study, we found that changes o…

BackgroundE2 is important in follicular development. During monitoring of stimulated cycles, serum levels of E2 are expected to increase steadily with follicle growth until final maturation. Unexpected E2 decline before triggering is report…

IntroductionWith ongoing global lifestyle changes and economic development, the prevalence of hyperuricemia has steadily increased. Elevated levels of serum uric acid (SUA) have been linked to gestational diabetes mellitus (GDM); however, t…

ObjectiveThis study investigates the MRI characteristics of primary and metastatic adult granulosa cell tumor with normal estrogen levels (AGCT-NEL) to enhance clinical understanding and diagnostic accuracy of this disease.MethodsWe collect…

BackgroundNeuraxial anesthesia is the gold standard for cesarean sections, but general anesthesia is sometimes necessary, especially in emergency cases. Anaphylactic shock due to succinylcholine, a commonly used neuromuscular blocking agent…

ObjectiveAdditive human menopausal gonadotropin (HMG)/recombinant luteinizing hormone (r-LH) to follicle-stimulating hormone (FSH) can improve pregnancy outcomes in patients with poor ovarian response during assisted reproductive procedures…

PurposeTo investigate the relationship between blood lead levels (BLLs) and IVF clinical outcomes in infertile females and to further explore the possible involvement of granulosa cell (GC) endoplasmic reticulum (ER) stress in the process.M…

OBJECTIVE: While infertility affects about 15% of women during their reproductive years, its long-term impact on stroke mortality after this period remains unclear. This study aims to investigate the association between infertility and stro…

ObjectiveTo investigate the interaction between atosiban and growth hormone (GH) as adjuvants in frozen-thawed embryo transfer (FET) cycles.MethodA total of 11627 patients who underwent FET at Xiamen University Affiliated Chenggong Hospital…

BackgroundGenome instability plays a crucial role in promoting tumor development. Germline mutations in genes responsible for DNA repair are often associated with familial cancer syndromes. A noticeable exception is the CHEK1 gene. Despite …

This study aimed to investigate the changes of serum carbohydrate antigen 125 (CA125) and prostaglandin E2 (PGE2) in patients with adenomyosis before and after treatment with high-intensity focused ultrasound (HIFU) combined with gonadotrop…

INTRODUCTION: Endometriosis (EM) is a multifactorial disease that affects 10 - 15% of women of reproductive age. Additionally, 30-50% of women with EM suffer from infertility. The mechanism of infertility caused by EM has not yet been consi…

ObjectiveTo investigate the feasibility of performing frozen-thawed high-quality single blastocyst transfer in women of different ages.MethodsA total of 1,279 women were divided into four groups: a 38-40-year-old group (n = 147), 35-37-year…

[This corrects the article DOI: 10.3389/fendo.2024.1433930.].

Abnormal granulosa cell (GC) death contributes to cyclophosphamide (CTX) induced primary ovarian insufficiency (POI). To investigate the contribution of GCs to POI, gene profiles of GCs exposed to CTX were assessed using RNA-Seq and bioinfo…

Ovarian cancer, a group of heterogeneous diseases, presents with extensive characteristics with the highest mortality among gynecological malignancies. Accurate and early diagnosis of ovarian cancer is of great significance. Here, we presen…

BackgroundThe timely identification and management of ovarian cancer are critical determinants of patient prognosis. In this study, we developed and validated a deep learning radiomics nomogram (DLR_Nomogram) based on ultrasound (US) imagin…

INTRODUCTION: The microbial community plays a crucial role in the pathological microenvironment. However, the structure of the microbial community within endometriotic lesions and its impact on the microenvironment is still limited. METHOD…

STUDY OBJECTIVE: To investigate whether different timings of GnRH-a downregulation affected assisted reproductive outcomes in infertile women with moderate-to-severe intrauterine adhesions (IUAs) accompanied by adenomyosis. DESIGN: A retro…

Study objectivesPolycystic ovary syndrome (PCOS) confers a high risk of obstructive sleep apnea (OSA). Here we investigated the effect of OSA on first in vitro fertilization (IVF) cycle metrics and outcomes in patients with PCOS.MethodsThis…

BackgroundPrior research showed that elevated serum uric acid (SUA) levels in women with polycystic ovary syndrome (PCOS) before in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) treatment can lead to a lower rate of liv…