Li X

Endometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs…

Background and objectivePoly(ADP-ribose) polymerase inhibitors (PARPis) have fundamentally changed the treatment paradigm for patients with ovarian cancer, especially in tumors with homologous recombination deficiency (HRD). However, acquir…

Adenomyosis is a prevalent disorder of the archimetra, historically conflated with endometriosis but possessing a unique pathobiological trajectory. This review synthesises current molecular evidence to propose a unified mechanistic framewo…

Primary vaginal cancer is a rare malignant tumor; its pathogenesis remains unclear and only a limited number of cases have been documented in the literature. The present report outlines a rare case of primary vaginal endometrioid adenocarci…

BackgroundThe relationship between the vascular flow index (VFI) of the endometrium and the pregnancy outcome in the frozen embryo transfer (FET) cycle remains controversial, and there is currently no recommended optimal range for VFI.Objec…

Precancers, defined as normal-appearing or morphologically altered tissues with a risk of oncogenesis, exhibit various detectable manifestations across anatomical sites, including epithelial dysplasia, metaplasia, hyperplasia, and stromal f…

Oral delivery of protein and peptide therapeutics (PPs) offers a non-invasive, patient-friendly alternative to parenteral administration, yet faces multiple formidable barriers due to the complex gastrointestinal (GI) environment. This revi…

Biofilm accumulation and subsequent implant-related infections pose significant challenges in the biomedical field. Photocatalytic coatings hold promise for antimicrobial efficacy; however, their effectiveness in dynamic polymicrobial infec…

ObjectiveTo investigate the interaction effects of anti-Müllerian hormone (AMH), antral follicle count (AFC), basal follicle-stimulating hormone (FSH), and endometrial thickness on the outcomes of assisted reproductive technology (ART).Meth…

Tumor immune escape is a major challenge in cancer treatment, and targeted immune escape therapy has become a key strategy for cancer treatment. As an important deubiquitinating enzyme, ubiquitin-specific protease 10 (USP10) participates in…

Adenomyosis is a chronic gynecological disorder characterized by ectopic endometrial tissue within the myometrium, leading to pelvic pain, menorrhagia, and infertility. Increasing evidence implicates dysregulated Wnt/beta-catenin signaling …

Background/Objective: RNA modifications, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), N1-methyladenosine (m1A), pseudouridine (Ψ), N4-acetylcytidine (ac4C), 5-methoxycarbonylmethyl-2-thiouridine (mcm5…

BackgroundHepatocellular carcinoma (HCC) mainly develops in cases of fibrosis and cirrhosis and is accompanied by intestinal flora disorder. HCC also affects CD8+ T cell immune function. 5,7-Dimethoxyflavone (DMF), an active flavonoid with …

BackgroundChronic endometritis (CE) is an inflammatory condition characterized by endometrial plasmacyte infiltration. The diagnosis and treatment of CE have attracted more and more attention. This article aimed to analyze the relevant keyw…

Currently, hormonal therapy for endometriosis faces challenges in achieving a balance between treatment and preserving the chance of pregnancy. Therefore, the development of non-hormonal therapy holds significant clinical importance. Angiog…

Endometriosis is an estrogen-dependent disease that severely affects the physical and mental health of women of childbearing age. Due to the significant side effects of traditional hormone therapies, non-hormonal treatment strategies are ur…

Multifunctional small-molecule theranostic agents hold significant clinical potential for non-invasive endometriosis (EMS) management. Current EMS treatment faces challenges due to imprecise lesion localization and therapy-associated side e…

BACKGROUND: To discover the related factors of ovarian reserve function and explore the relationship between AFC and AMH. METHODS: In this study, a retrospective analysis of endometriosis cases from January 2022 to December 2023 was perfor…

At present, there is unclear on the risk factors of recurrence after myomectomy. In this study, we hope to provide reference for the choice of treatment for patients with uterine fibroids and provide basis for the subsequent prediction of r…

IntroductionRecurrent pregnancy loss (RPL) is a complex condition with multifactorial causes. This study aimed to characterize the microbial composition of endometrial fluid in RPL patients compared with healthy controls.MethodsA total of 1…

While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F…

PurposeTo investigate the dynamic changes of serum Anti-Müllerian Hormone (AMH) and Inhibin B (INHB) during controlled ovarian hyperstimulation (COH) in patients with polycystic ovarian syndrome (PCOS) and analyze their correlation with COH…

BackgroundOvarian maldescent is a rare congenital anomaly in which one or both ovaries are positioned abnormally above the pelvic brim. However, the potential relationship between ovarian maldescent and infertility remains poorly understood…

Relative Fat Mass (RFM) is an emerging body fat measurement index that more accurately reflects the distribution of visceral fat. This study aimed to investigate the association between RFM and female infertility. We utilized data from the …