Study types
- other 4
- article 1
- meta-analysis 1
Condition tags
- endometriosis 6
- infertility 3
- adenomyosis 1
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Menstrual symptoms may negatively impact academic achievement, but rigorous population-based studies are lacking. 2,698 participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) self-reported heavy or prolonged bleeding…
Earlier menopause is associated with increased risks of type 2 diabetes, osteoporosis, heart disease, depression, and mortality. Although menopause is typically defined as the absence of menstruation for 12 consecutive months, deriving age …
Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female i…
OBJECTIVE: To study the relationship between conception by assisted reproductive technology (ART) and risk of endometriosis/adenomyosis in female offspring. DESIGN: National registry-based cohort study. SUBJECTS: We studied 449,611 female…
AIMS: To assess the risk of hypertension and cardiovascular disease (CVD) in relation to the number of assisted reproductive technologies (ART) cycles. METHODS AND RESULTS: In this registry-based study, we studied women in Norway born betw…
Aim: Hypotheses about what phenotypes to include in causal analyses, that in turn can have clinical and policy implications, can be guided by hypothesis-free approaches leveraging the epigenome, for example.Materials & methods: Minimally ad…
Study questionAre cardiovascular disease (CVD) risk factors causally associated with higher risk of infertility among women and men?Summary answerWe found evidence to support a causal relationship between smoking initiation and history of i…
Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 6…
ImportanceThe use of assisted reproductive technologies (ARTs) is steadily increasing worldwide. The outcomes associated with treatment for an individual's long-term health, including risk of cardiovascular disease (CVD), remain largely unk…
Problematic menstrual cycle features, including irregular periods, severe pain, heavy bleeding, absence of periods, frequent or infrequent cycles, and premenstrual symptoms, are experienced by high proportions of females and can have substa…
Age at natural menopause (ANM) is associated with a range of health-related traits, including bone health, female reproductive cancers, and cardiometabolic health. Our objective was to conduct a Mendelian randomization phenome-wide associat…
ImportanceMenstrual cycle characteristics may be associated with an increased risk of cardiovascular disease (CVD). However, existing studies are limited, and few have explored the mediating role of established CVD risk factors.ObjectiveTo …
A few studies indicate that women with prolonged time-to-pregnancy (TTP) have an increased risk of cardiovascular disease (CVD). This has not been studied in men. We evaluated CVD risk by self-reported TTP among parous women (n = 64,064) an…
OBJECTIVES: Sex differences in respiratory physiology and predilection for developing chronic obstructive pulmonary disease (COPD) have been documented, suggesting that female sex hormones may influence pathogenesis. We investigated whether…