Chen L

Endometriosis is a common disease among women of childbearing age, and endoplasmic reticulum stress (ERS), a response involved in regulating protein homeostasis, has been linked to its pathogenesis. To identify ERS-related hub genes, this s…

Adenomyosis (AM) is characterized as a chronic and progressive disorder with limited therapeutic strategies available. Myometrial fibrosis is a prominent pathological feature of AM, yet the underlying molecular mechanisms remain elusive. Th…

BackgroundIntra-abdominal hemorrhage (IAH) is a rare but potentially life-threatening complication of ultrasound-guided transvanginal oocyte pick up (OPU). Despite the widespread use of OPU in assisted reproductive technology, minor hemorrh…

ObjectiveRecurrent spontaneous abortion (RSA) is a major pregnancy complication with unclear pathogenesis. This study aims to investigate the role of miR-20b-5p and its downstream target HIF-1α in trophoblast function and RSA pathogenesis.M…

Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications. However, the role of protein palmitoylation in oocyte aging ha…

The substantial apprehension facing young cancer patients revolves around the onset of chemotherapy-induced premature ovarian failure (POF), primarily linked to damage inflicted upon granulosa cells (GCs). The inquiry delves into the protec…

Mitochondria, the powerhouse of the cell, orchestrate a plethora of critical functions, including energy production, metabolic regulation, programmed cell death, and signal transduction. Their pivotal role in the pathogenesis of numerous di…

Endometriosis significantly impacts women's health and fertility, with cell aging playing a crucial role in its development. This study utilized a multi-omic summary Mendelian randomization (SMR) analysis, integrating genome-wide associatio…

ObjectiveWe aimed to analyze the correlation between the neutrophil-to-lymphocyte ratio (NLR), and the treatment outcomes for infertile women after in vitro fertilization (IVF) using embryo transfer technology.MethodsThis retrospective stud…

Patients with systemic lupus erythematosus (SLE) often have decreased fertility. Gene translation is crucial to oocyte meiosis and development. However, it remains unclear how SLE affects this process. Here, we used single-cell transcriptom…

BackgroundPoor ovarian response (POR) is a pathological condition characterized by inadequate ovarian response to gonadotropin stimulation in patients undergoing in vitro fertilization and embryo transfer. It represents a primary cause of f…

Postpartum uterine necrosis is a rare and serious complication. The uterine tissue becomes devascularized and then causes endometrial necrosis and even myometrial necrosis, usually combing with uterine infection. To clear the infection, hys…

BackgroundInfertility is a growing global challenge that affects millions of people, and various factors influence female reproductive health. This study examined the association between inflammatory indicators, nutritional status, metaboli…

BackgroundPelvic abscesses represent acute gynecological emergencies requiring timely intervention. This study evaluated prognostic predictors and treatment modalities in patients with pelvic abscesses.MethodsWe conducted a retrospective an…

Osteopontin (OPN) is an extracellular matrix protein secreted by various types of cells, and serves multiple physiological roles such as modulating bone cell maturation, immune responses, tissue repair and regeneration. Aberrant OPN express…

OBJECTIVES: Adenomyosis (AM) is a chronic disorder that significantly impacts women's health and quality of life worldwide, particularly by causing progressive impairment in fertility. This study aimed to summarize and visualize the literat…

RationaleSepsis following hysteroscopy is an rare complication, with current evidence suggesting that routine prophylactic antibiotic administration may not be warranted. However, this does not imply that we should disregard vigilance regar…

Abstract The characteristic of endometriosis is that the endometrial tissue grows in non-endometrial parts such as the pelvis and ovaries, leading to infertility and chronic pain. However, its pathophysiology is still unclear. Using high-p…

The pathogenesis of stress urinary incontinence (SUI), a condition common in women, remains to be fully elucidated. This study revealed that the incidence of SUI is associated with mitochondrial homeostasis dysregulation following oxidative…

PurposeTo improve the oral absorption of relugolix (RLGL), which has low oral bioavailability due to its low solubility and being a substrate of P-glycoprotein (P-gp). A solid self-microemulsifying drug delivery system of relugolix (RLGL-S-…

Endometriosis manifests as ectopic endometrial tissue outside the uterine cavity. This common disease can sometimes appear at unusual anatomical sites or within the intestinal tract, growing as a lesion and mimicking cancer. Such tumor-like…

Background: Assisted reproductive therapy (ART) has been utilized as an effective therapeutic strategy for addressing infertility worldwide, and one of the key determinants of ART success is the acquisition of high-quality embryos through i…

BackgroundEffective communication between radiologists and clinicians is essential for optimal inflammatory bowel disease (IBD) management. Structured reporting (SR) of imaging reports may enhance interdisciplinary communication and clinica…

ObjectivesEarly menarche affects the mental and physical health of girls, but the evidence of the association between birth weight/rapid weight gain and early menarche is inconsistent. We conduct this systematic review and meta-analysis to …

ObjectiveTo analyze the effect of autologous platelet-rich plasma (PRP) intrauterine perfusion on the clinical outcomes of frozen-thawed embryo transfer in patients with chronic endometritis.MethodsA retrospective continuous cohort of 219 p…