Fregni F

No ORCID on file · 11 papers in corpus · active 2013-2026

Study types

  • other 1

Condition tags

  • endometriosis 1
  • chronic_pelvic_pain 1
2026
Development and Validation of the Brief Inventory of Treatment Expectations in Chronic Pain (BITEC).
European journal of pain (London, England) ·doi:10.1002/ejp.70211

BackgroundExpectations shape therapeutic outcomes, yet their systematic assessment remains limited in clinical and research settings. To address this gap, we developed and validated the Brief Instrument for the Assessment of Treatment Expec…

2026
Sense of Coherence in the Trauma-Fibromyalgia Relationship: Mediation and Moderation Findings from a 2099-Participant Cohort.
European journal of investigation in health, psychology and education ·doi:10.3390/ejihpe16030045

BackgroundThe biopsychosocial model positions fibromyalgia (FM) as the result of altered pain modulation shaped by trauma, psychological vulnerability, and structural stressors. The Sense of Coherence (SOC) may be a key resilience factor ex…

2021
Mapping of predictors of the disengagement of the descending inhibitory pain modulation system in fibromyalgia: an exploratory study.
British journal of pain ·doi:10.1177/2049463720920760

BackgroundThe main symptoms of fibromyalgia comprise diffuse pain, disability, depressive symptoms, catastrophizing, sleep disruption and fatigue, associated with dysfunction of the descending pain-modulating system (DPMS).ObjectivesWe aime…

2020
Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial.
PloS one ·doi:10.1371/journal.pone.0231379

This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive im…

2019
The Effects of Melatonin on the Descending Pain Inhibitory System and Neural Plasticity Markers in Breast Cancer Patients Receiving Chemotherapy: Randomized, Double-Blinded, Placebo-Controlled Trial.
Frontiers in pharmacology ·doi:10.3389/fphar.2019.01382

Background: Adjuvant chemotherapy for breast cancer (ACBC) has been associated with fatigue, pain, depressive symptoms, and disturbed sleep. And, previous studies in non-cancer patients showed that melatonin could improve the descending pai…

2019
Transcranial Direct Current Stimulation to Improve the Dysfunction of Descending Pain Modulatory System Related to Opioids in Chronic Non-cancer Pain: An Integrative Review of Neurobiology and Meta-Analysis.
Frontiers in neuroscience ·doi:10.3389/fnins.2019.01218

Background: Opioid long-term therapy can produce tolerance, opioid-induced hyperalgesia (OIH), and it induces dysfunction in pain descending pain inhibitory system (DPIS). Objectives: This integrative review with meta-analysis aimed: (i) To…

2017
Preoperative transcranial direct current stimulation: Exploration of a novel strategy to enhance neuroplasticity before surgery to control postoperative pain. A randomized sham-controlled study.
PloS one ·doi:10.1371/journal.pone.0187013

BackgroundAn imbalance in the excitatory/inhibitory systems in the pain networks may explain the persistent chronic pain after hallux valgus surgery. Thus, to contra-regulate this dysfunction, the use of transcranial direct current stimulat…

other 2015
Clinical Value of Serum Neuroplasticity Mediators in Identifying the Central Sensitivity Syndrome in Patients With Chronic Pain With and Without Structural Pathology
The Clinical journal of pain ·doi:10.1097/AJP.0000000000000194

BACKGROUND AND OBJECTIVES: Central sensitivity syndrome (CSS) encompasses disorders with overlapping symptoms in a spectrum of structural pathology from persistent somatic nociception (eg, osteoarthritis) to absence of tissue injury such as…

2015
Combined neuromodulatory interventions in acute experimental pain: assessment of melatonin and non-invasive brain stimulation.
Frontiers in behavioral neuroscience ·doi:10.3389/fnbeh.2015.00077

Transcranial direct current stimulation (tDCS) and melatonin can effectively treat pain. Given their potentially complementary mechanisms of action, their combination could have a synergistic effect. Thus, we tested the hypothesis that comp…

2015
Investigation of central nervous system dysfunction in chronic pelvic pain using magnetic resonance spectroscopy and noninvasive brain stimulation.
Pain practice : the official journal of World Institute of Pain ·doi:10.1111/papr.12202

BackgroundRecent studies demonstrate that chronic pelvic pain is associated with altered afferent sensory input resulting in maladaptive changes in the neural circuitry of pain. To better understand the central changes associated with chron…

2013
A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects.
PloS one ·doi:10.1371/journal.pone.0074107

BackgroundPrevious studies have suggested that melatonin may produce antinociception through peripheral and central mechanisms. Based on the preliminary encouraging results of studies of the effects of melatonin on pain modulation, the impo…