Yu L

Endometriosis (EMs) is a gynecological disorder affecting women of reproductive age. It is characterized by the ectopic implantation and infiltration of endometrial-like tissue and is associated with significant effects on fertility, pelvic…

OBJECTIVE: To address the need for more objective and reproducible preoperative diagnosis of deep infiltrating endometriosis (DIE), this study aimed to develop and validate a weighted ensemble machine learning (ML) model using multimodal ma…

Ovarian cancer remains a significant global health burden, with high-grade serous ovarian cancer (HGSOC) representing the most lethal subtype. Bulk RNA-seq analysis revealed KLK5 (Kallikrein-5, a serine protease) upregulation in ovarian can…

OBJECTIVE: This study aimed to explore the feasibility of developing and internal validating machine learning (ML) models for post-retrieval ovarian hyperstimulation syndrome (OHSS) risk stratification in patients undergoing assisted reprod…

BACKGROUND: Endometrial thickness (EMT) is widely monitored in assisted reproductive technology as a marker of implantation potential, yet its precise association with pregnancy and perinatal outcomes in frozen embryo transfer (FET) cycles …

This study explores the effect of pyriform sperm heads on basic semen parameters, advanced sperm functions, and assisted reproductive technology outcomes. From 2300 patients with pyriform sperm heads in semen, a cohort of 59 couples from th…

Objectives: Diminished ovarian reserve (DOR) significantly compromises in vitro fertilization (IVF) success. Although systemic markers such as anti-Müllerian hormone (AMH) serve as valuable clinical indicators of the ovarian reserve, they l…

Endocrine-disrupting chemicals (EDCs) are ubiquitous and highly persistent environmental contaminants. Human exposure occurs through multiple routes, including dietary ingestion, water consumption, inhalation, and dermal contact, posing sus…

BACKGROUND: Immune tolerance breakdown at the maternal-fetal interface is implicated in unexplained recurrent pregnancy loss (URPL), but the interplay between T cell hyperactivation and dendritic cells (DCs)-mediated signaling remains poorl…

Adenomyosis (AM) commonly affects women of reproductive age and can impair female fertility, yet its diagnosis and pathogenesis remain challenging. We compared serum IgG1 Fc‑glycosylation profiles between AM patients (n = 30) and non‑AM con…

Background: High-grade serous ovarian carcinoma (HGSOC) is the most common and lethal subtype of epithelial ovarian cancer and is frequently diagnosed at advanced stages. Because currently available blood-based biomarkers have limited perfo…

BACKGROUND: The benefit of adjuvant chemotherapy for stage I ovarian endometrioid carcinoma (OEC) remains controversial. Hence, the study sought to explore its value in stage I OEC patients. METHODS: Stage I OEC patients (1988-2018) were i…

BACKGROUND: Polycystic ovary syndrome (PCOS) is widely acknowledged as the prevailing reproductive endocrine disorder accompanied by numerous metabolic dysfunctions. However, there has been a lack of systematic examination regarding the ami…

BACKGROUND & OBJECTIVE: To assess the association of assisted reproductive technologies (ART) conception with postpartum hemorrhage (PPH) during the peripartum and postpartum periods. METHODS: Clinical records of 11,497 patients enrolled i…

PURPOSE: In vitro fertilization and embryo transfer (IVF-ET) has become crucial for infertile couples. Previous studies have suggested that multiple ETs are associated with increased risks of preterm birth and low birth weight. The current …

UNLABELLED: Vulvar lichen sclerosus (VLS) is a chronic skin condition affecting the vulva, causing significant discomfort, but its etiology in prepubertal girls remains poorly understood. VLS presents with itching, irritation, and pain. Rec…

Perfluorooctane sulfonate (PFOS) is a widely used chemical in industrial production. It can be introduced into the environment through multiple pathways and exhibits resistance to degradation. Recent research has demonstrated a significant …

PURPOSE: To investigate the effect of intraoperative low-dose esketamine administered at anesthesia induction on postoperative quality of recovery in total laparoscopic hysterectomy. PATIENTS AND METHODS: One-hundred six female patients sc…

Endometriosis (EMs) and recurrent miscarriage (RM) represent major reproductive health challenges. This study investigates the involvement of endothelial-mesenchymal transition (EndMT) in these conditions through integrative bioinformatics …

BACKGROUND: Observational studies have suggested an association between endometriosis and glycemic traits, but causality remains unclear. We used bidirectional and multivariate Mendelian randomization (MR) to examine the causal effect of gl…

BACKGROUND: Chronic salpingitis is one of the most common causes of female infertility. Luteal support is a critical step for embryo transfer. Here, we evaluated the effects of two luteal support regimens, intramuscular progesterone (IMP) a…

BACKGROUND: Intrauterine adhesions (IUAs) are a significant clinical challenge, affecting reproductive health and leading to infertility or recurrent pregnancy loss. Understanding the molecular mechanisms underlying IUA prevention is crucia…

PURPOSE: To identify potential biomarkers and the molecular mechanisms associated with repeated implantation failure (RIF), three microarray datasets, GSE71331 (lncRNA + mRNA), GSE111974 (lncRNA + mRNA), and GSE71332 (miRNA), were retrieved…

OBJECTIVE: To study biomarkers to develop a novel diagnosis model for endometriosis and validate it using clinical samples. DESIGN: We used publicly available data sets and weighted gene coexpression network analysis to identify differenti…