Maria P. Vélez

Background Chronic pelvic pain (CPP) is often described as a multisystem pain condition, yet population-level evidence on adolescent antecedents is scarce. We examined whether healthcare encounters for gynecologic or reproductive morbidity …

STUDY QUESTION: What is the incidence of premature ovarian insufficiency (POI) and its associated factors in Ontario, Canada, between 1995 and 2019? SUMMARY ANSWER: The incidence of POI increased after 2011, driven primarily by non-iatroge…

Study questionTo what extent does multiple birth mediate the association between fertility treatment and congenital anomalies?Summary answerMultiple birth explained only a modest proportion of the increased risk of congenital anomalies asso…

BACKGROUND: Fertility treatments have been associated with an increased risk of congenital anomalies. Most studies have compared births conceived through fertility treatment with unassisted conceptions; consequently, these estimates reflect…

Abstract Study question Is endometriosis associated with reduced ovarian reserve, as measured by Anti-Müllerian hormone (AMH) levels, independent of surgical intervention? Summary answer Endometriosis was associated with lower AMH levels, s…

Reproductive health unfolds across the lifespan, and individuals may move through diverse pathways - including infertility, chronic gynecologic conditions such as endometriosis, pregnancy complications, assisted reproduction or gestational …

BACKGROUND: Maternal chronic conditions are implicated as risk factors for congenital anomalies, but few studies have assessed reproductive conditions such as endometriosis. Given the association between endometriosis and infertility requir…

OBJECTIVE: To determine the future priorities for ectopic pregnancy research. DESIGN: Potential research questions were collated from an initial international survey, a systematic review of clinical practice guidelines, and Cochrane system…

STUDY QUESTION: What is the association between infertility with or without fertility treatment and incident onset of systemic autoimmune rheumatic disease (SARD) among women who give birth? SUMMARY ANSWER: Women who experienced infertilit…

We completed a retrospective population-based cohort study using administrative data from Ontario female patients from 1993 to 2015 to examine the association between a diagnosis of endometriosis and stroke. We identified 166 853 female pat…

STUDY OBJECTIVE: This study aimed to evaluate the association between surgeon characteristics and postoperative surgical outcomes, including rates of complications, recurrence of symptoms, fertility outcomes, and need for reoperation for in…

Endometriosis is a chronic inflammatory condition that has been linked to mental health outcomes. We conducted a population-based, retrospective, matched cohort study using administrative health data (2010-2022) from Ontario, Canada, to ass…

STUDY QUESTION: Are different types of thyroid cancer treatment among young women associated with adverse reproductive outcomes? SUMMARY ANSWER: All types of thyroid cancer treatment were associated with infertility diagnosis and early men…

PURPOSE: To examine the effects of Hodgkin's lymphoma and its treatment on reproductive health in female adolescent and young adults (AYA). METHODS: We conducted a retrospective, population-based, matched-cohort study of female patients wi…

BACKGROUND: Endometriosis is a chronic gynecologic disorder that leads to considerable pain and a reduced quality of life. Although its physiological manifestations have been explored, its impact on mental health is less well defined. Exist…

This population-based cohort evaluated the association between endometriosis and severe maternal morbidity (SMM), and the mediating effect of infertility and fertility treatment. Included were all singleton deliveries in Ontario between 200…

BACKGROUND: Endometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to e…

IMPORTANCE: Previous studies on the risk of childhood autism spectrum disorder (ASD) following fertility treatment did not account for the infertility itself or the mediating effect of obstetrical and neonatal factors. OBJECTIVE: To assess…

Study questionIs the risk of attention-deficit hyperactivity disorder (ADHD) increased in children born to mothers with infertility, or after receipt of fertility treatment, compared to mothers with unassisted conception?Summary answerInfer…

OBJECTIVE: Caesarean section (CS) is more common following infertility treatment (IT) but the reasons why remain unclear and confounded. The Robson 10-Group Classification System (TGCS) may further explain variation in CS rates. We assessed…

OBJECTIVE: To evaluate the association between endometriosis and adverse pregnancy outcomes. DESIGN: Population-based retrospective cohort study using linked universal health databases through ICES Ontario. PATIENT(S): All singleton pregn…

We conducted a population-based, retrospective, matched-cohort study to examine the impact of breast cancer diagnosis and treatment on fertility outcomes. Relative risks of infertility, childbirth, premature ovarian insufficiency (POI; age …