Liu W

G protein-coupled receptors (GPCRs) serve as central hubs in tumor signal transduction and microenvironment regulation. However, their therapeutic exploitation is confounded by a fundamental complexity: GPCR functions are exquisitely contex…

OBJECTIVE: To investigate the association of triglyceride-glucose index (TyG) and uric acid to high-density lipoprotein cholesterol ratio (UHR) with the prevalence of uterine fibroids (UF), and to evaluate the dose-response relationship and…

Infertility is a complex and sensitive phenomenon experienced by many couples worldwide. Our study investigated the causal effects of 486 serum metabolites on infertility using a Mendelian randomization (MR) approach, providing insights int…

Ovarian cancer is a malignant tumor of the female reproductive system with a high mortality rate. Currently, China has the highest number of new ovarian cancer cases worldwide; therefore, preoperative diagnosis is of particular importance. …

Endometriosis, an estrogen-dependent inflammatory disorder prevalent in reproductive-age women, is characterized by the growth of endometrial-like tissue outside the uterine cavity, leading to chronic pain and infertility. Current therapeut…

OBJECTIVES: To determine the association between hysterectomy performed for benign indications and the risk of developing BC. METHODS: A literature search was conducted in PubMed, Embase, and the Cochrane Library from database inception up…

BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been shown to disrupt normal follicular development and ovulation. However, it is unknown which specific PFAS in follicular fluid negatively impact oocyte development and…

BACKGROUND: Endometriosis affects up to 15% of women of reproductive age and can lead to various symptoms. More than 200 million people worldwide are at risk of higher than safe levels of arsenic exposure through drinking water. Studies inv…

As a heterogeneous disease, endometriosis is associated with diagnostic delay. Delayed diagnosis, physical discomfort, hormone therapy, and inconvenience in daily life and work all contribute to a decreased quality of life for endometriosis…

Oxidative stress is a significant factor affecting reproductive efficiency in dairy cows, contributing to conditions such as endometritis that impair fertility and milk production. This study investigates the molecular mechanisms by which b…

Infertility impacts 48 million couples globally, and accumulating evidence suggests that micronutrients potentially influence reproductive health. This Mendelian randomization study investigates causal relationships between 15 micronutrient…

This review article focuses on the role of choline in ovarian follicular development, regulated by nutrient-epigenetic interactions. Choline, a key feed additive, participates in DNA methylation and steroid hormone synthesis via its methyl …

The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent implantation failure (RIF). The role of cilia as one …

Potassium permanganate (KMnO4) is a commercially available antiseptic used in bovine intrauterine lavage to manage postpartum infections. Lipopolysaccharides (LPS) are well-studied for their ability to induce inflammation and oxidative stre…

RESEARCH QUESTION: To investigate the underlying mechanisms driving the opposing effects of transforming growth factor-beta 1 (TGFβ1) on the proliferation of control (CESCs) and ectopic (EESCs) endometrial stromal cells. DESIGN: Cell proli…

BACKGROUND: The Life's Essential 8 (LE8) score has been associated with various health outcomes, but its relationship with female infertility remains unclear. METHODS: This study investigated the relationship between LE8 and infertility in…

BACKGROUND: This study aims to evaluate the impact of adjuvant chemotherapy on cancer-specific survival (CSS) and overall survival (OS) in patients with Stage IA ovarian clear cell carcinoma (OCCC) using data from the Surveillance, Epidemio…

Endometrial dysfunction underlies many common gynecologic disorders, such as endometriosis, endometrial cancer, intrauterine adhesions, and endometritis, which affect many women around the world. Extracellular vesicles play an important rol…

BACKGROUND: Uterine fibroids(UF), while histologically benign, constitute a pervasive yet inequitable epidemiological phenomenon characterized by disproportionately distributed morbidity burdens that correlate asymmetrically with regional d…

BACKGROUND: This retrospective study aimed to examine the influence of hormonal and metabolic parameters across varying body mass index (BMI) levels on embryo quality and pregnancy outcomes in fresh embryo transfer cycles using assisted rep…

Sheep (Ovis aries) are valuable biomedical models for studying human reproductive biology, however, the transcriptional dynamics underlying their ovarian development remain insufficiently characterized. In this study, we profiled 61,649 sin…

Lactate is an indispensable substance in various cellular physiological functions and plays regulatory roles in different aspects of energy metabolism and signal transduction. Lactylation (Kla), a key pathway through which lactate exerts it…

Ming Wei,1 Weijun Liu,1– 3 Zhangqiang Zheng,1 Yun Liu,1 Xingzhou Zhang1 1Tianjin NanKai Hospital, Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Scientific Research, Tianjin Key Laboratory of Acute Abdomen D…

INTRODUCTION: Endometriosis is a prevalent chronic gynecological disease, characterized by the growth of endometrial glands and stroma outside the uterus and by the presence of chronic inflammatory lesions. This condition is one of the most…

RESEARCH QUESTION: What are the lipidomic alterations in the myometrial tissue from adenomyotic lesions? DESIGN: This was a two-centre, prospective, observational study conducted between July 2023 and June 2024. Forty-four premenopausal pa…