Chiu YH

Study questionWhat are the comparative pregnancy outcomes in women who receive up to six consecutive cycles of ovulation induction with letrozole versus clomiphene citrate?Summary answerThe risks of pregnancy, livebirth, multiple gestation,…

BackgroundRandomized trials of supplementation with antioxidant mixtures during infertility treatment show no benefit on pregnancy or live birth rate. However, the roles of individual antioxidants are poorly understood. We examined the asso…

ImportanceAnimal experiments suggest that ingestion of pesticide mixtures at environmentally relevant concentrations decreases the number of live-born offspring. Whether the same is true in humans is unknown.ObjectiveTo examine the associat…

BackgroundSome dietary factors have been linked to outcomes of infertility treatment with assisted reproductive technology (ART), but the role of intake of meats and other protein-rich foods remains unclear.ObjectiveThe aim of this manuscri…

Study questionAre serum polyunsaturated fatty acids (PUFA) concentrations, including omega-3 (ω3-PUFA) and omega-6 (ω6-PUFA), related to ART outcomes?Summary answerSerum levels of long-chain ω3-PUFA were positively associated with probabili…

BackgroundThe Environment and Reproductive Health (EARTH) Study is an ongoing prospective preconception cohort designed to investigate the impact of environmental, nutritional, and lifestyle factors among both women and men on fertility and…

BackgroundSubfertile women are at increased risk of glucose intolerance in pregnancy. Based on epidemiologic studies, exposure to certain phthalates is associated with diabetes, elevated glucose, and increased insulin resistance.ObjectivesT…

Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy.…

Study questionIs pre-treatment alcohol and caffeine intake associated with infertility treatment outcomes among women undergoing ART?Summary answerLow to moderate alcohol and caffeine intakes in the year prior to infertility treatment were …

ObjectiveTo evaluate the association between protein intake (amount and type) and antral follicle count (AFC).DesignProspective cohort.SettingAcademic fertility centre.PopulationTwo hundred and sixty-five women undergoing fertility treatmen…

Study questionIs dairy food consumption associated with live birth among women undergoing infertility treatment?Summary answerThere was a positive association between total dairy food consumption and live birth among women ≥35 years of age.…

Experimental data in rodents suggest that the effects of bisphenol A (BPA) on oocyte development may be modified by dietary methyl donors. Whether the same interaction exists in humans is unknown. We evaluated whether intake of methyl donor…

ObjectiveTo evaluate the relationship between pretreatment intake of whole grains and outcomes of IVF.DesignProspective cohort study.SettingAcademic medical center.Patient(s)A total of 273 women who collectively underwent 438 IVF cycles.Int…

Disparities in women's reproductive health outcomes across the life course have been well-documented. Endocrine disrupting chemicals may be one factor driving disparities, as studies suggest exposure to certain environmental endocrine disru…

Di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), a non-phthalate plasticizer, was introduced commercially in 2002 as an alternative to ortho-phthalate esters because of its favorable toxicological profile. However, the potential health ef…

Study questionAre urinary phthalate metabolites associated with reduced antral follicle growth among women in an infertility setting?Summary answerHigher urinary concentrations of di(2-ethylhexyl) phthalate (DEHP) metabolites were associate…

BackgroundPreconceptional folate and vitamin B-12 have been linked to beneficial reproductive outcomes in both natural pregnancies and those after assisted reproductive technology (ART) treatment.ObjectiveThe objective of the study was to e…

Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. I…

Study questionAre urinary BPA concentrations associated with in vitro fertilization (IVF) outcomes among women attending an academic fertility center?Summary answerUrinary BPA concentrations were not associated with adverse reproductive and…