Silvia Vannuccini

• Adenomyosis shows a strong association with heavy menstrual bleeding. • Endometriosis is linked to more severe pain-related symptoms than adenomyosis. • Dyspareunia is common in both conditions and lacks discriminatory value. • Coexistenc…

OBJECTIVE: To assess the prevalence of proliferative endometrial disorders in women with histologically confirmed adenomyosis and to evaluate the independent association between adenomyosis and each lesion type. DESIGN: Retrospective cohor…

Endometriosis, traditionally viewed as a gynecological condition, is increasingly recognized as a systemic disease due to its frequent association with inflammatory and autoimmune comorbidities. Recent molecular and genetic insights reveal …

BACKGROUND: Endometriosis is a chronic endocrine and inflammatory disease commonly presenting with dysmenorrhea, pelvic pain, and/or infertility. Despite the importance of menstrual symptoms, the impact of menstruation on stress is still po…

Autoimmune and inflammatory rheumatic diseases (RDs) are more prevalent in women and often affect gynecological health. Particularly, heavy menstrual bleeding (HMB) and dysmenorrhea are more common in patients with RD. A link between RDs an…

Adenomyosis, a menstruation-related uterine disorder, refers to the presence of endometrial stroma and glands within the myometrium and is typically observed in reproductive-age women. The pathogenesis explaining the migration, persistence,…

BACKGROUND: To date, there are no clear guidelines available on the treatment of adenomyosis-associated pelvic pain (AAPP); however, numerous hormonal treatments (HTs) are currently being used off-label. We conducted a systematic review and…

OBJECTIVE: To assess the effects of relugolix combination therapy in women with uterine fibroids (UFs) and concomitant ultrasound-diagnosed adenomyosis. DESIGN: This post hoc analysis used pooled data from completers of the pivotal LIBERTY …

• Endometriosis and fibromyalgia frequently co-occur, even though in more than two-thirds of cases, the diagnosis of endometriosis preceded that of fibromyalgia. • Patients with endometriosis and fibromyalgia exhibit distinct clinical chara…

PROBLEM: Immunological abnormalities are well recognized in the pathogenesis of endometriosis and the co-existence of endometriosis with inflammatory bowel disease (IBD) and celiac disease (CD), along with other systemic immune disorders, i…

PURPOSE OF REVIEW: Endometriosis is a chronic inflammatory condition that significantly affects women's quality of life and fertility. Despite advancements in treatment, many areas of uncertainty persist in clinical management. This review …

BACKGROUND: Adenomyosis is a uterine disorder causing menstruation-related symptoms such as dysmenorrhea, heavy menstrual bleeding (HMB) and dyspareunia. A long-term management of the disease is required. Hormonal drugs are the most used, i…

INTRODUCTION: Dysmenorrhea is a painful symptom associated with uterine contractions and menstrual bleeding and is treated by administering analgesic drugs. Since progesterone receptors (PRs) have a major role in regulating uterine tissues …

RESEARCH QUESTION: How do comorbidities and their prevalence differ between patients with adenomyosis alone and patients with both adenomyosis and endometriosis? DESIGN: A prospective observational study compared the presence of comorbidit…

Endometriosis is a chronic gynecologic disease of reproductive-age women, causing menstrual pain and infertility. Endocrine and inflammatory mechanisms drive its development, with estrogen/progesterone imbalance contributing to extrauterine…

Abnormal uterine bleeding (AUB) is a bleeding from the uterine corpus that is abnormal in regularity, volume, frequency or duration. It encompasses heavy menstrual bleeding, irregular menstrual bleeding and intermenstrual bleeding, which ar…

RESEARCH QUESTION: What is the prevalence of adenomyosis at ultrasonography among adolescents and young women reporting dysmenorrhoea and/or heavy menstrual bleeding (HMB)? DESIGN: This observational cohort study involved adolescents and y…

Endometriosis is a complex disease and still many areas of uncertainty exist on the clinical management, from the diagnosis to the treatment. The modern diagnostic workup should include the family history (including genetic and epigenetic f…

Adenomyosis is a common benign uterine disorders and patients may present dysmenorrhea, dyspareunia, abnormal uterine bleeding (AUB) and infertility. The treatment is very complex, including medical, surgical or radiological approaches. Hor…

• Women with newly diagnosed endometriosis reported an unbalanced dietary pattern. • An unfavorable balance between pro-inflammatory and anti-inflammatory food was found in women with endometriosis. • Patient with endometriosis reported hig…

• Endometriosis with associated mental health symptoms lowers health-related quality of life. • Symptoms of anxiety and depression are associated with a greater number of endometriosis symptoms. • Further research is required and should rep…