Roby KF

No ORCID on file · 4 papers in corpus · active 2014-2024
2024
Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer.
Cell death & disease ·doi:10.1038/s41419-024-06717-3

Advanced epithelial ovarian cancer (EOC) survival rates are dishearteningly low, with ~25% surviving beyond 5 years. Evidence suggests that cancer stem cells contribute to acquired chemoresistance and tumor recurrence. Here, we show that IR…

2018
Histone demethylase KDM4A and KDM4B expression in granulosa cells from women undergoing in vitro fertilization.
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-018-1151-3

PurposeTo assess expression of the histone demethylases KDM4A and KDM4B in granulosa collected from women undergoing oocyte retrieval and to determine if expression was related to pregnancy outcome.MethodsCumulus and mural granulosa cells w…

2015
Neonatal Progesterone Programs Adult Uterine Responses to Progesterone and Susceptibility to Uterine Dysfunction.
Endocrinology ·doi:10.1210/en.2015-1397

In this report, we investigated the consequences of neonatal progesterone exposure on adult rat uterine function. Female pups were subcutaneously injected with vehicle or progesterone from postnatal days 3 to 9. Early progesterone exposure …

2014
Generation of Esr1-knockout rats using zinc finger nuclease-mediated genome editing.
Endocrinology ·doi:10.1210/en.2013-2150

Estrogens play pivotal roles in development and function of many organ systems, including the reproductive system. We have generated estrogen receptor 1 (Esr1)-knockout rats using zinc finger nuclease (ZFN) genome targeting. mRNAs encoding …