H. Kühl

The effects of extended regimens of combined oral contraceptives (COCs) on carbohydrate metabolism are largely unknown. The present study compared the effects of a COC containing 30 microg ethinylestradiol and 2 mg dienogest (EE/DNG) in con…

In einer prospektiven, randomisierten, multizentrischen Studie wurden insgesamt 1315 Frauen im Alter zwischen 18 und 40 Jahren mit 30µg Ethinylestradiol + 2mg Dienogest entweder für 13 konventionelle (21 Tabletten) oder 4 Langzyklen (84 Tab…

Fragestellung: Retrospektiven Untersuchungen haben gezeigt, dass die Fertilität nach dem Absetzen eines oralen Kontrazeptivums (OC) für die Dauer von bis zu 2 Jahren negativ beeinflusst werden kann. Bei repräsentativen Umfragen nahmen in Dr…

This is the first double-blind, controlled, randomized study comparing the effect of different estrogen components in oral contraceptives (OCs) on hemostasis variables. Four groups of 25 women each were treated for six cycles with monophasi…

OBJECTIVE: Two randomized comparative multicenter studies were conducted to establish the endometrial safety and tolerability of a triphasic sequential hormone replacement estradiol valerate/medroxyprogesterone acetate (E2V/MPA) therapy reg…

In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on thyroid hormone parameters, cortisol, aldosterone, endothelin-1 and angiotensin II was investigated. Four groups …

In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on lipid metabolism was investigated. Four groups composed of 25 volunteers each (mean age 26.1 +/- 4.5 years; body …