Zhang Y

PurposeTo investigate the impact of storage duration after vitrification of cleavage-stage embryos on pregnancy and perinatal outcomes.MethodsA retrospective study was conducted on 4205 infertile patients underwent frozen-thawed embryo tran…

ImportanceTonsillectomy has long been scrutinized for its potential long-term impacts on health, with conflicting evidence linking it to increased risks of several diseases, such as cancer, psychiatric disorders, and immune dysfunctions.Obj…

Upon exposure to biofluids, engineered nanoparticles (NPs) spontaneously form reproducible biomolecular coronas via selective diverse biomolecule adsorption. The corona characterization of metabolites poses greater analytical challenges tha…

OBJECTIVE: Bromocriptine has emerged as a potential treatment for adenomyosis. This study aimed to identify genes associated with Bromocriptine sensitivity and explore the biological processes and cell-type-specific expression patterns invo…

Hypoxia stress seriously affects the survival of aquatic animals. However, little is known about the regulation mechanism under hypoxia stress; hence, it is important to fully clarify this regulation to improve the hypoxia tolerance of aqua…

RESEARCH QUESTION: Is surgery effective in decreasing iron deposition in the ovarian tissue surrounding an ovarian endometrioma? DESIGN: This cohort study was conducted in China between July 2023 and April 2024. Seventy-nine patients with …

RESEARCH QUESTION: Do iron metabolism and ferroptosis influence oocyte and embryo quality in patients with endometriosis undergoing IVF/intracytoplasmic sperm injection (ICSI), or in a mouse model? DESIGN: Fifty-seven patients with laparos…

ETHNOPHARMACOLOGICAL RELEVANCE: Gonadotropin-releasing hormone agonists (GnRH-a) often induce menopausal symptoms, negatively affecting women's psychological, emotional, and physical health. Kuntai capsule is widely used in clinical practic…

ObjectiveTo compare the therapeutic effects of laparoscopic recanalization and laparotomy recanalization on tubal patency restoration after tubal sterilization.MethodsA retrospective analysis was conducted on the clinical data of 122 patien…

The cryopreservation of ovarian tissue can induce oxidative damage. In this study, we investigated whether low-intensity pulsed ultrasound (LIPUS) can mitigate this oxidative damage and examined the underlying molecular mechanisms. Ovarian …

Panax ginseng C.A. Meyer, a renowned medicinal herb, exerts many of its systemic effects through intricate interactions with the gut microbiota, a relationship that also addresses the challenge of its own limited oral bioavailability. This …

BACKGROUND: Predicting in vitro fertilization (IVF) pregnancy outcomes is crucial for individualized decision-making. However, due to complex interactions among multiple factors, accurate manual integration and assessment are challenging. T…

Gestational diabetes mellitus (GDM), is a prevalent metabolic disorder associated with placental dysfunction and adverse pregnancy outcomes. Emerging evidence points to endoplasmic reticulum (ER) stress as a potential initiating factor in G…

Osteoporosis is a skeletal pathology characterized by decreased bone mass and structural deterioration resulting from an imbalance in bone metabolic processes. Estrogen deficiency in postmenopausal women leads to an increased risk of osteop…

Ovarian senescence is accompanied by inflammatory responses, yet the underlying mechanism remains incompletely elucidated. In this study, transcriptome sequencing was performed on ovarian granulosa cells from advanced-age patients and norma…

ETHNOPHARMACOLOGICAL RELEVANCE: Endometriosis (EMs) is a prevalent and challenging gynecological disease and current therapeutic outcomes are suboptimal. Traditional Chinese medicine (TCM) has numerous advantages in treating EMs. Bushen Wen…

This study explores how quercetin may treat endometriosis (EMs) by combining network pharmacology and transcriptome sequencing approaches. Through network pharmacology, 132 shared targets between quercetin and EMs were identified, with KEGG…

ObjectiveTo explore the independent metabolic and ultrasonographic factors associated with clinical pregnancy in patients with polycystic ovary syndrome (PCOS) undergoing frozen-thawed embryo transfer (FET) cycles, develop and validate a no…

Metabolism-regulating microspheres have evolved from conventional drug carriers into active platforms capable of spatiotemporally reprogramming pathological metabolic networks. Chronic diseases are increasingly understood to be driven by me…

PURPOSE: This study investigates metabolic profiles in follicular fluid of patients with endometriosis (EM), polycystic ovary syndrome (PCOS), tubal blockage (TB), and unexplained infertility (UEI), assessing their associations with follicu…

BackgroundOocyte aneuploidy is a major cause of pregnancy failure in women of advanced maternal age (AMA), and current assisted reproductive technologies offer limited effective strategies to prevent age-related decline in oocyte quality. T…

OBJECTIVES: To evaluate the long-term therapeutic efficacy of laparoscopy combined with transvaginal ultrasound-guided microwave ablation (MWA) for adenomyosis and to identify independent risk factors for postoperative symptomatic recurrenc…

For women with diminished ovarian reserve or of advanced age, controlled ovarian stimulation presents a significant challenge during in vitro fertilization cycles. This multi-center, open-label, randomized controlled trial enrolled 318 wome…

Polycystic ovary syndrome (PCOS), one of the most common endocrine and reproductive disorders in women of reproductive age, is frequently complicated by insulin resistance (IR), which affects 50%–80% of PCOS patients and is strongly associa…

ObjectiveGallbladder cancer (GBC) is a rare gastrointestinal malignancy with a global 5-year survival rate of less than 5%. Early diagnosis is challenging owing to the lack of specific clinical symptoms. Additionally, the high heterogeneity…