Kumar R

Idiopathic recurrent pregnancy loss (RPL) affects 1-2% of human pregnancies, yet the underlying molecular causes are poorly understood. Here we identify defective Protein Arginine Methyltransferase 1 (PRMT1) function in trophoblast progenit…

Endometriosis is a complex, estrogen-dependent disease with limited effective treatments that often focus on symptom management rather than addressing the underlying pathology. Current therapies, such as progestins and GnRH agonists, have s…

BACKGROUND: The use of health systems data (HSD) such as patient records and prescriptions is expanding within clinical trials to improve efficiency, reduce participant burden, and enhance real‑world relevance. However, challenges remain ar…

BACKGROUND: Abnormal uterine bleeding (AUB), affecting 3–30% of women of reproductive age, can lead to serious physical complications such as anaemia and infertility, and also negatively impacts mental well-being, social participation, and …

Sexually transmitted infections (STIs) are a global public health concern, particularly among women of reproductive age and leads to severe health complications. Married women, despite being perceived as low-risk, are often excessively affe…

In this developing era, increased anthropogenic activities result in the contamination of natural resources. Different kinds of pollutants threaten the water quality being crucial for the existence of life. There are different sources and r…

Ovarian cancer (OC) is the most lethal gynecologic malignancy, characterized by multiple histological subtypes, each with distinct pathological and clinical features. Current treatment approaches include cytotoxic chemotherapies, poly(ADP-r…

A roundtable on gynaecological health in South Asia engaged speakers from four countries to share insights on the current context, challenges and priorities for action in the region. Women's gynaecological needs beyond maternal health are o…

Nanomaterials offer significant potential for non-invasive multimodal imaging due to their multifunctionality and tunable nanoscale features. Advances in their design and conjugation with organic and inorganic materials have enhanced their …

The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). …

Pesticides are widely used to control pests, but their widespread use raises concerns regarding potential health risks for humans. There are several routes through which pesticides can be ingested, inhaled, and absorbed, resulting in acute …

Endometriosis is a debilitating disease affecting 190 million women worldwide and the greatest single contributor to infertility. The most broadly accepted etiology is that uterine endometrial cells retrogradely enter the peritoneum during …

India is native to many tribal communities: Bharia (Madhya Pradesh), Bihl (Rajasthan), Santhal (Bihar, Jharkhand), Bodo (Assam, West Bengal), and many more. They reside in isolated geographical regions, which poses challenges in reaching ou…

INTRODUCTION: Heterogeneous and nonspecific symptoms make invasive endometriosis a difficult entity to diagnose. Small lesions with absent associated changes can be easily missed in cross-sectional imaging. Even when the lesions satisfy the…

Adipose tissue-derived stromal vascular fraction (AdSVF) comprises a heterogeneous cell population, including the multipotent mesenchymal stem cells, hematopoietic stem cells, immune cells, endothelial cells, fibroblasts, and pericytes. As …

Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought to affect disease outcome. However, our understanding of the spatial relationship…

INTRODUCTION: Teratomas are those tumors which are derived from the totipotent cells. They may manifest at any site. Ovary is the most common site for teratomas. Ovarian teratomas may be immature and mature depending on the elements they ha…

Abstract BackgroundDisruption in biological clock due to genetic variations is associated with increased occurrence of cancers such as breast, ovary, prostate, gastrointestinal and hematological malignancies. Circadian rhythm genes regulat…

Ovarian cancer (OC), a multifaceted and genetically heterogeneous malignancy is one of the most common cancers among women. The aim of the study is to unravel the genetic factors associated with OC and the extent of genetic heterogeneity in…

In recent literature, mucoceles have been discovered to be in the appendix vermiformis or in the nasal sinuses. Although rare, colonic mucoceles, as well as rectal mucoceles, have also been encountered. Furthermore, colonic mucoceles arisin…

STUDY QUESTION: Can the priorities for future research in infertility be identified? SUMMARY ANSWER: The top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction…

Primary encapsulating peritoneal sclerosis is an enigmatic entity that may be erroneously diagnosed as abdominal tuberculosis in tuberculosis-endemic regions. In patients with a history of recurrent intestinal obstruction, a high index of s…

The purposes of this study were to revisit the utility of ultrasonography (USG) as a primary imaging modality in acute appendicitis (AA) and to establish the role of CT scan as a second-line/problem-solving modality. All cases of suspected …