Dawra R

No ORCID on file · 3 papers in corpus · active 2011-2022
2022
Chronic pancreatitis in a caerulein-induced mouse model is associated with an altered gut microbiome.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] ·doi:10.1016/j.pan.2021.12.003

BackgroundChronic pancreatitis (CP) is an inflammatory disease of the pancreas with loss of exocrine/endocrine functions as well as development of fibrosis. Dysbiosis of gut microbiome has been shown to be involved in the pathogenesis of ma…

2016
Release of Cathepsin B in Cytosol Causes Cell Death in Acute Pancreatitis.
Gastroenterology ·doi:10.1053/j.gastro.2016.06.042

Background & aimsExperimental studies in acute pancreatitis (AP) suggest a strong association of acinar cell injury with cathepsin B-dependent intracellular activation of trypsin. However, the molecular events subsequent to trypsin activati…

2011
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.
Gastroenterology ·doi:10.1053/j.gastro.2011.08.033

Background & aimsThe role of trypsinogen activation in the pathogenesis of acute pancreatitis (AP) has not been clearly established.MethodsWe generated and characterized mice lacking trypsinogen isoform 7 (T7) gene (T(-/-)). The effects of …