Garg PK

Chronic pancreatitis is a progressive fibroinflammatory disease of the pancreas that causes recurrent or chronic abdominal pain and functional insufficiency. Chronic pancreatitis follows the conceptual model of acinar cell injury, which lea…

IMPORTANCE: Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas with a prevalence of 42 to 73 per 100 000 adults in the United States. OBSERVATIONS: Both genetic and environmental factors are thought to…

Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas. The currently available treatment of CP is aimed at controlling symptoms and managing complications. Unfortunately, no specific treatment is available to halt …

BackgroundA definition of chronic pancreatitis (CP) is needed for diagnosis and distinguishing CP from other disorders. Previous definitions focused on morphology. Advances in epidemiology, genetics, molecular biology, modeling and other di…

Background & aimsThe role of trypsinogen activation in the pathogenesis of acute pancreatitis (AP) has not been clearly established.MethodsWe generated and characterized mice lacking trypsinogen isoform 7 (T7) gene (T(-/-)). The effects of …

SIGNIFICANCE: Chronic pancreatitis (CP) is a progressive, inflammatory disease of the pancreas leading to slow destruction of pancreatic parenchyma and progressive fibrosis. The pathophysiological mechanism of CP is not well understood. RE…