Manhardt E

No ORCID on file · 3 papers in corpus · active 2022-2024
2024
eLife ·doi:10.7554/elife.89830

Investigating the human fallopian tube (FT) microbiota has significant implications for understanding the pathogenesis of ovarian cancer (OC). In this large prospective study, we collected swabs intraoperatively from the FT and other surgic…

2024
Gynecologic Oncology ·doi:10.1016/j.ygyno.2024.07.690

BackgroundIndividuals with germline BRCA1 and BRCA2 pathogenic variants (BRCA carriers) are at high risk of developing high grade serous ovarian carcinoma (HGSC). HGSC is predominantly driven by TP53 mutations, but mutations in this gene ar…

2022
Cancer research communications ·doi:10.1158/2767-9764.crc-22-0314

Current screening methods for ovarian cancer (OC) have failed to demonstrate a significant reduction in mortality. Uterine lavage combined with TP53 ultra-deep sequencing for the detection of disseminated OC cells has emerged as a promising…