Feng Y

ObjectiveTo analyze the correlation between angiopoietin-like protein 8 (ANGPTL8) and polycystic ovary syndrome (PCOS) and explore the clinical diagnostic value of ANGPTL8 in PCOS.MethodsIn this retrospective case-control study, we included…

Introduction and aimsOral squamous cell carcinoma (OSCC) is a common malignant tumour of the head and neck region. In recent years, the relationship between pyroptosis and tumours has received increasing attention. However, its regulatory m…

BACKGROUND: Current guidelines recommend laparoscopic cystectomy for ovarian endometrioma (OMA) ≥4 cm before fertility treatment, yet cystectomy inevitably damages ovarian reserve. While recent large-scale studies have confirmed that cystec…

BACKGROUND: Endometriosis is a systemic gynecological disorder affecting ~ 10% of reproductive-aged women and shares pathophysiological features with cardiovascular disease (CVD). However, its associations with cardiac remodeling and CVD ri…

Diminished ovarian reserve (DOR) is associated with poor reproductive outcomes; however, the underlying molecular mechanisms-particularly those involving the regulation of granulosa cell (GC) function by exosomal microRNAs (miRNAs) derived …

Endometriosis (EMs) is characterized by dysregulated persistence and enhanced invasiveness of ectopic endometrial cells. Current treatment strategies remain limited by high recurrence rates and considerable adverse effects. Although iron ov…

Endometriosis is a common, chronic gynecological disorder characterized by the presence of endometrial-like tissue outside the uterine cavity, frequently associated with significant morbidities such as pelvic pain and infertility. Elucidati…

BackgroundThe clinical benefit of immunotherapy in ovarian cancer (OC) remains limited. The primary reason is not simply a lack of immune activation, but rather the marked spatiotemporal heterogeneity of the tumour immune microenvironment. …

BACKGROUND: This study utilizes data from two principal sources: the National Health and Nutrition Examination Survey (NHANES) conducted in the United States from 1999 to 2020 and the China Health and Retirement Longitudinal Study (CHARLS) …

PurposeTo explore the influencing factors of clinical pregnancy outcomes for in vitro fertilization/intracytoplasmic single sperm injection and embryo transfer (IVF/ICSI-ET) patients, and to establish a predictive algorithm to predict the r…

BackgroundUltra-processed foods (UPFs) have been linked to multiple adverse health outcomes; however, their association with infertility remains unclear. We conducted a systematic review and meta-analysis to evaluate the relationship betwee…

OBJECTIVES: To investigate the clinical characteristics of deep infiltrating endometriosis (DIE), summarize the experiences in its diagnosis and management, and identify potential peripheral blood indicators associated with the severity of …

BACKGROUND: The cervicovaginal microbiome-spanning from the vagina to endometrium-remains undercharacterized in endometriosis-associated infertility. Objective: To determine whether combined vaginal and cervical microbial profiles predict f…

ObjectiveAlthough struma ovarii (SO) is mostly benign, it is frequently overtreated due to challenges in differentiating it from malignant tumors. Therefore, the purpose of this study was to investigate the clinical, laboratory, ultrasonogr…

Small cell neuroendocrine carcinoma of the cervix (SCNEC) is a rare and highly aggressive malignancy with a poor prognosis. We report the case of a 36-year-old nulliparous woman with a history of HPV-18 infection and repeated cytology showi…

Previous observational studies have suggested an association between natural hair color and the risk of endometriosis; however, the causal relationship remains unclear. Here, we conducted a two-sample Mendelian randomization (MR) study to e…

Ovarian cancer (OC) is a highly lethal gynecologic malignancy because of the absence of specific early symptoms and reliable biomarkers, most OC patients are often diagnosed at advanced stages, resulting in poor prognosis. Traditional tissu…

Abstract Background Endometriosis is a systemic gynecological disorder that affects approximately 10% of women of reproductive age and shares certain pathophysiological features with cardiovascular disease (CVD). Despite this, the connecti…

The ovary is a crucial gonadal organ that supports female reproductive and endocrine functions. Ovarian aging can result in decreased fertility and dysfunction across multiple organs. Research has demonstrated that cellular senescence in va…

OBJECTIVE: To evaluate various body fat indicators under weight management on the time to complete response (CR) in overweight patients undergoing fertility-sparing treatment for endometrial cancer (EC) or atypical hyperplasia (AEH). METHOD…

BackgroundThe prevention, management, and treatment of female cancers among women of childbearing age (WCBA) are crucial strategies for achieving the objectives outlined in the World Health Organization (WHO) Global Breast Cancer Initiative…

Endometriosis (EM) significantly impacts the quality of life, and its diagnosis currently relies on surgery, which carries risks and may miss early lesions. Noninvasive biomarkers are urgently needed for early diagnosis and personalized tre…

Pelvic organ prolapse (POP) significantly impacts patients' quality of life, and current treatment options remain limited due to high recurrence rates, making the exploration of new therapeutic targets essential. Using data from the FinnGen…

Long interspersed element 1 (LINE-1) retrotransposons are repetitive sequences that can move within the genome by an autonomous mechanism. To limit their mutagenic potential, benign cells restrict LINE-1 expression through molecular mechani…

OBJECTIVE: Endometriosis increases ovarian cancer (OC) risk through genetic mutations, chronic inflammation, and hormonal dysregulation, yet the underlying molecular pathways remain underexplored. This study aims to identify endometriosis-a…