Uma Thiruchelvam

No ORCID on file · 6 papers in corpus · active 2012-2018

Study types

  • article 4
  • review 2

Condition tags

  • endometriosis 4
  • mesh:D004715 3
  • infertility 3
article 2018
Uterine natural killer cell progenitor populations predict successful implantation in women with endometriosis‐associated infertility
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12817

PROBLEM: Uterine natural killer (uNK) cells play a critical role early in gestation. As we previously identified altered uNK cell development in endometriosis-associated infertility, we herein sought to characterize natural killer (NK) cell…

article 2016
Increased uNK Progenitor Cells in Women With Endometriosis and Infertility are Associated With Low Levels of Endometrial Stem Cell Factor
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12486

PROBLEM: Uterine natural killer (uNK) cells play a significant role in successful human pregnancy. Having previously demonstrated uNK cell progenitors in human endometrium, we hypothesized that abnormal uNK cell maturation contributes to in…

article 2015
Cortisol regulates the paracrine action of macrophages by inducing vasoactive gene expression in endometrial cells
·doi:10.1189/jlb.5a0215-061rr

The human endometrium undergoes inflammation and tissue repair during menstruation. We hypothesized that the local availability of bioactive glucocorticoids plays an important role in immune cell-vascular cell interactions in endometrium du…

review 2015
Natural Killer Cells: Key Players in Endometriosis
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12408

Endometriosis affects more than 10% of women, causing significant pain and morbidity. It is also a significant cause of infertility. The aetiology of the disease remains an enigma, and the mechanisms responsible for the associated infertili…

article 2014
Vital uNK growth factors are reduced in endometrial tissue from women with endometriosis resulting in an accumulation of uNK progenitor cells
·doi:10.1530/repabs.1.p010

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)

review 2012
The importance of the macrophage within the human endometrium
·doi:10.1189/jlb.0712327

The human endometrium is exposed to cyclical fluctuations of ovarian-derived sex steroids resulting in proliferation, differentiation (decidualization), and menstruation. An influx of leukocytes (up to 15% macrophages) occurs during the lat…