Wang X

Abstract Background Postoperative fever (PF) and postoperative bloodstream infections (PBSIs) are common and severe complications following gynecological surgery, yet they receive less focus than surgical site infections. This study aime…

Advanced maternal age is associated with adverse pregnancy outcomes. However, the impact of changes in maternal physiology, biochemistry, vaginal microbiome, and its metabolites related to reproductive age on pregnancy outcomes is uncertain…

Chronic endometritis (CE) is a persistent inflammatory disorder of the endometrium, associated with infertility, recurrent pregnancy loss, and implantation failure. Diagnosis primarily depends on hysteroscopy and immunohistochemistry, while…

BACKGROUND: This retrospective cohort study aimed to evaluate the impact of insulin resistance (IR) on clinical outcomes in polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injectio…

Endometriosis is a prevalent gynecological disorder worldwide that significantly impairs the quality of life of patients and imposes a substantial economic burden. The limited efficacy and adverse effects of current pharmacological and surg…

Oral dysbiosis increases the risk of oral diseases and systemic diseases, with many related conditions overlapping with systemic diseases triggered by gut dysbiosis. Studies have shown that the oral cavity serves as an endogenous reservoir …

OBJECTIVE: This study aimed to develop a machine learning (ML) model integrated with SHapley Additive exPlanations (SHAP) analysis to predict postpartum hemorrhage (PPH) following vaginal deliveries, offering a potential tool for personaliz…

Endometriosis (EMs) and recurrent miscarriage (RM) represent major reproductive health challenges. This study investigates the involvement of endothelial-mesenchymal transition (EndMT) in these conditions through integrative bioinformatics …

Nanomaterials are increasingly applied in biomedicine and have significant potential in reproductive medicine. However, because they can impact germ cells, use of nanomaterials could represent a "double-edged sword", whose benefits must be …

Ovarian cancer (OC) is a prevalent malignancy; however, the role of kinesin light chain 3 (KLC3) in OC remains unclear. The present study conducted a comprehensive investigation of KLC3 using bioinformatics analysis, as well as in vitro and…

BACKGROUND: With the increasing use of assisted reproductive technology (ART) as a solution for infertility, understanding patient knowledge, attitudes, and practices (KAP) is essential. This study aimed to assess the KAP of infertile women…

BACKGROUND: Endometriosis is a chronic gynecological disorder affecting approximately 10% of women of reproductive age. It commonly presents with pelvic pain, dysmenorrhea, and infertility, imposing substantial physical, psychological, and …

INTRODUCTION: Recurrent implantation failure (RIF) is a major challenge in reproductive medicine, and emerging evidence suggests that alterations in the endometrial microbiota may play a critical role in its pathogenesis. To identify the ma…

Endometriosis (EMs) is a chronic inflammatory disorder featured by infertility and pain. The role of N6-methyladenosine (m6A) in EMs has been evidenced. This study investigated the molecular mechanism of METTL14-m6A-KLF4 modulating macropha…

Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they ofte…

PURPOSE: Polycystic ovary syndrome (PCOS) is currently recognized as a condition that affects several systems in the body, including the reproductive, endocrine, and cardiovascular systems. Prevalent among teenagers and women of reproductiv…

BACKGROUND: MicroRNAs (miRNAs) exert a crucial role in the progression of lung cancer (LC) and can serve as prognostic biomarkers. AIM: To analyze the prognostic value of miR-3613-5p and its regulatory effect on XPO6 in LC, this study was …

Abstract Background/Objectives: To study the molecular classification of endometrial cancer combined with adenomyosis and compare its differences in molecular classification and clinicopathological characteristics with endometriosis ade…

INTRODUCTION: Metabolic syndrome is a serious public health concern across the globe. However, the typical metabolites and mechanisms underlying the decreased fertility related to metabolic syndrome is still elusive. OBJECTIVES: The aim of…

Endometriosis (EMS) is an estrogen-dependent disorder that affects about 10% of reproductive-age women. EMS affects female neuroendocrine and reproductive functions, greatly compromising female reproductive health and quality of life. Howev…

INTRODUCTION: Endometriosis is a common chronic gynecological condition that affects approximately 10% of women of reproductive age worldwide. METHODS: This study utilized large-scale genome-wide association study data and explored the cau…

PURPOSE: Obstetric rectal buttonhole tear (ORBT) is a rare but serious complication of vaginal delivery, associated with rectovaginal fistula and fecal incontinence. Standardized management protocols are lacking. PATIENTS AND METHODS: We c…

INTRODUCTION: The nuclear receptor TR4 binding protein, TRA16, has been implicated in lung carcinogenesis; however, its broader role across diverse human cancers remains poorly understood. Understanding TRA16's involvement in cancer biology…

Objective To identify novel and noninvasive biomarkers for the diagnosis of adenomyosis and to provide potential therapeutic targets. Design We conducted a cross-sectional study using data from 110 women of reproductive age who underwent pe…

BACKGROUND: This study assessed the impact of chronic hepatitis B virus (HBV) infection on ovarian reserve in women. METHODS: We analyzed data from 38,861 infertile women undergoing their first in vitro fertilization (IVF) treatment (2016-…