Wu H

Recurrent implantation failure (RIF) remains a major challenge in assisted reproductive technology, and the molecular mechanisms underlying endometrial receptivity are incompletely understood. This study aimed to comprehensively characteriz…

BACKGROUND: With the increasing rate of cesarean sections, long-term complications have received growing attention, and the cesarean scar diverticulum (CSD) is one of the 3 major complications of cesarean section. While rupture during pregn…

BACKGROUND: Sperm DNA fragmentation index (DFI) has emerged as a potential marker of male fertility, but its clinical value in assisted reproductive technology (ART) remains debated. This study aimed to investigate the association between s…

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of childbearing age. In addition, it is a heterogeneous disease with numerous etiologies, multiple levels, and uneven manifestation. In patients …

BACKGROUND: The selection of a frozen-thawed embryo transfer (FET) strategy requires balancing the potential for improved clinical pregnancy and live birth outcomes against the risk of multiple pregnancy. However, comprehensive evaluations …

BACKGROUND: This study evaluated the effects of different ovulation trigger strategies on pregnancy outcomes in letrozole-stimulated and modified natural frozen–thawed embryo transfer (L-FET and mNC-FET) cycles. METHODS: A total of 2053 eli…

BACKGROUND: Single-port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA-1000. METHODS: In this dual centre, single-arm, prospective study, eligible…

BACKGROUND: Little is known about the oncologic results of patients with low-grade endometrial stromal sarcoma (LGESS) with fertility preservation. This study investigated the prognosis of fertility-sparing surgeries and relevant obstetrica…

Ovarian aging, marked by a progressive diminution of oocyte quality and quantity, is a major contributor to declining female fertility and age-related reproductive disorders. However, transcript-level changes underlying this process remain …

Hydrogels are highly hydrated three-dimensional polymeric network materials that have attracted considerable attention in medical and biomedical fields owing to their favorable chemical modifiability, physical tunability, biocompatibility, …

Abstract Hypoxia, a state of reduced oxygen availability, drives endometrial disease progression by inducing cellular reprogramming that promotes inflammation, angiogenesis, and aberrant cell survival in endometriosis and endometrial cance…

PURPOSE: To investigate the impact of storage duration after vitrification of cleavage-stage embryos on pregnancy and perinatal outcomes. METHODS: A retrospective study was conducted on 4205 infertile patients underwent frozen-thawed embry…

ObjectiveThis study aims to investigate the role and regulatory mechanisms of PTP1B in acute pancreatitis.MethodsAn in vitro AP cell model was established using Caerulin (CAE). Cells were subsequently treated with MSI-1436 (PTP1B inhibitor)…

OBJECTIVE: To perform a preliminary, hypothesis-generating evaluation of the association between intraovarian injection of platelet-rich plasma (PRP) combined with peripheral blood mononuclear cells (PBMCs) and ovarian response parameters i…

BACKGROUND: Diminished ovarian reserve (DOR) is associated with impaired female fertility; however, its molecular mechanisms remain incompletely understood. Our previous studies found that individuals with DOR have lower levels of microRNA-…

OBJECTIVE: To investigate oncological and reproductive outcomes in patients with mismatch repair-deficient (MMRd) endometrial endometrioid carcinoma (EEC) or atypical endometrial hyperplasia (AEH) undergoing fertility-preserving treatment t…

Globally, approximately 80-95% of women of reproductive age are affected by premenstrual syndrome and menstrual-related symptoms, which significantly impair their quality of life. Although non-steroidal anti-inflammatory drugs and hormonal …

BACKGROUND: Ovarian pregnancies at advanced gestational ages are exceedingly rare in clinical practice. The infrequency of this condition, coupled with the nonspecific nature of its symptoms and signs, renders preoperative diagnosis extreme…

The independent causal effects of interrelated lifestyle behaviors and psychological states on women's gynecologic and obstetric health remain incompletely understood. We conducted a comprehensive Mendelian randomization (MR) study to disen…

BACKGROUND: Endometriosis (EMS) and inflammatory bowel disease (IBD) are both chronic inflammatory disorders with overlapping clinical features, suggesting a potentially shared etiology. Although epidemiological studies have reported an ass…

Surgery continues to be a mainstay of treatment for patients with symptomatic fibroids. Hysterectomy is an option for those desiring definitive treatment and myomectomy is preferred for those that have not yet completed childbearing or wish…

Endometriosis is a debilitating chronic inflammatory disorder driven by extensive molecular reprogramming. Despite significant bench research into its pathogenesis, translating these molecular discoveries into clinical practices that improv…

INTRODUCTION: Studies indicate that endometriosis (EMs) is associated with inflammation and metabolic abnormalities. The Remnant Cholesterol Inflammatory Index (RCII) concurrently reflects both inflammatory and metabolic status. However, th…