Winneker RC

No ORCID on file · 5 papers in corpus · active 2005-2009

Study types

  • other 3
  • article 1
  • review 1

Condition tags

  • endometriosis 5
other 2009
Novel progesterone receptor modulators with gene selective and context-dependent partial agonism
Biochemical pharmacology ·doi:10.1016/j.bcp.2008.10.016

Progesterone receptor (PR) modulators are used in contraception and post-menopausal hormone therapy, and are under clinical development for reproductive disorders such as uterine fibroids and endometriosis. Development of tissue selective P…

other 2008
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)
Journal of medicinal chemistry ·doi:10.1021/jm701080t

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previous…

other 2008
Development of an early biomarker for the ovarian liability of selective estrogen receptor modulators in rats
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2008.08.008

Selective estrogen receptor modulators (SERMs) have the potential to treat estrogen sensitive diseases such as uterine leiomyoma and endometriosis, which are prevalent in reproductive age women. However, SERMs also increase the risk of deve…

article 2006
Down-Regulation of Endometrial Matrix Metalloproteinase-3 and -7 Expressionin Vitroand Therapeutic Regression of Experimental Endometriosisin Vivoby a Novel Nonsteroidal Progesterone Receptor Agonist, Tanaproget
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2005-2024

CONTEXT: Endometriosis, the growth of endometrial tissue outside the uterus, is principally an estrogen-dependent disease. In contrast, exposure to progesterone during pregnancy or therapeutically has been shown to provide benefit to some w…

review 2005
Nonsteroidal progesterone receptor modulators: structure activity relationships
Seminars in reproductive medicine ·doi:10.1055/s-2005-864033

Progesterone, acting primarily via the progesterone receptor (PR), plays an essential role in the regulation of female reproduction. Steroidal progestins (i.e., PR agonists) are commonly used in women's health, such as in contraception and …