Andrew Fensome

No ORCID on file · 4 papers in corpus · active 2003-2008

Study types

  • article 2
  • other 1
  • review 1

Condition tags

  • endometriosis 4
other 2008
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)
Journal of medicinal chemistry ·doi:10.1021/jm701080t

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previous…

review 2005
Nonsteroidal progesterone receptor modulators: structure activity relationships
Seminars in reproductive medicine ·doi:10.1055/s-2005-864033

Progesterone, acting primarily via the progesterone receptor (PR), plays an essential role in the regulation of female reproduction. Steroidal progestins (i.e., PR agonists) are commonly used in women's health, such as in contraception and …

article 2003
Non-steroidal progesterone receptor modulators
·doi:10.1517/eotp.13.12.1839.22905

Progesterone (P4) plays an essential role in female reproduction and progesterone receptor (PR) agonists have been used in female contraceptives and in postmenopausal hormone therapy. Recent studies in women and non-human primates show that…

article 2003
Non-steroidal progesterone receptor modulators
·doi:10.1517/13543776.13.12.1839

Progesterone (P4) plays an essential role in female reproduction and progesterone receptor (PR) agonists have been used in female contraceptives and in postmenopausal hormone therapy. Recent studies in women and non-human primates show that…