Lac V

No ORCID on file · 4 papers in corpus · active 2017-2022

Study types

  • article 3
  • preprint 1

Condition tags

  • endometriosis 4
  • die_deep_infiltrating 2
  • infertility 1
article 2022
Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes
Fertility and sterility ·doi:10.1016/j.fertnstert.2022.05.030

OBJECTIVE: To investigate the heterogeneity of somatic cancer-driver mutations within patients and across endometriosis types. DESIGN: A single-center cohort, retrospective study. SETTING: Tertiary specialist-care center at a university h…

preprint 2021
Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes
·doi:10.1101/2021.04.12.21255355

Abstract Endometriosis symptoms are heterogeneous with controversy on whether it constitutes a single disease or multiple distinct types. Our previous work found recurrent somatic cancer-driver alterations in endometriosis; however, these h…

article 2018
Iatrogenic endometriosis harbors somatic cancer-driver mutations
Human Reproduction ·doi:10.1093/humrep/dey332

STUDY QUESTION: Does incisional endometriosis (IE) harbor somatic cancer-driver mutations? SUMMARY ANSWER: We found that approximately one-quarter of IE cases harbor somatic-cancer mutations, which commonly affect components of the MAPK/RAS…

article 2017
Cancer-Associated Mutations in Endometriosis without Cancer
The New England journal of medicine ·doi:10.1056/nejmoa1614814

BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benig…