Fok KL

No ORCID on file · 4 papers in corpus · active 2017-2024

Study types

  • other 1

Condition tags

  • endometriosis 1
  • infertility 1
2024
DEFB119 stratifies dysbiosis with distorted networks in the seminal microbiome associated with male infertility.
PNAS nexus ·doi:10.1093/pnasnexus/pgae419

Infertility is associated with the alteration of the seminal microbiome. However, the onset of dysbiosis remains controversial and the involvement of host factors remains elusive. This study investigates the alterations of the seminal micro…

2023
Epididymis cell atlas in a patient with a sex development disorder and a novel NR5A1 gene mutation.
Asian journal of andrology ·doi:10.4103/aja202226

This study aims to characterize the cell atlas of the epididymis derived from a 46,XY disorders of sex development (DSD) patient with a novel heterozygous mutation of the nuclear receptor subfamily 5 group A member 1 (NR5A1) gene. Next-gene…

other 2018
CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/β-Catenin Complex in Human Endometriosis
The American journal of pathology ·doi:10.1016/j.ajpath.2018.03.004

Epithelial-to-mesenchymal transition (EMT) is postulated to be a prerequisite for the establishment of endometriosis (EMS), a common reproductive disorder in women. Our previous studies have demonstrated the elevated expression of transmemb…

2017
CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways.
Oncotarget ·doi:10.18632/oncotarget.13624

CD147 null mutant male mice are infertile with arrested spermatogenesis and increased apoptotic germ cells. Our previous studies have shown that CD147 prevents apoptosis in mouse spermatocytes but not spermatogonia. However, the underlying …