Wang M

Polycystic ovary syndrome (PCOS) exacerbated by obesity represents a complex intersection of endocrine and immune dysregulation, significantly impairing reproductive and metabolic health. This characterizes the immune-inflammatory landscape…

BACKGROUND: Endometriosis is characterized by inflammation and fibrosis, in which cytokines and cytokine-macrophage interactions serve as critical mediators. However, the specific mechanisms that initiate the fibrotic cascade in endometrios…

BACKGROUND AND AIMS: Menstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, an…

The widely accepted theory of endometriosis posits that endometriosis stems from the translocation of endometrial tissue through the fallopian tubes into the abdominal cavity. However, the exact pathogenesis and critical molecules of endome…

OBJECTIVE: We aimed to compare the effects of the progestin-primed ovarian stimulation (PPOS) protocol and gonadotropin-releasing hormone antagonist (GnRH-A) protocol in women with different ovarian reserves who underwent assisted reproduct…

The Hippo pathway regulates many physiological processes, including development, tumor suppression, and wound healing. One understudied Hippo pathway component is PTPN14, an evolutionarily conserved tyrosine phosphatase that inhibits YAP/TA…

OBJECTIVES: This meta-analysis seeks to clarify the relationship between hysterectomy, oophorectomy, and the subsequent risk of developing breast cancer. METHODS: A comprehensive literature search was conducted across PubMed, the Cochrane …

OBJECTIVE: Limited evidence exists on the safety of inactivated COVID-19 vaccines and the optimal vaccination timing for women undergoing in vitro fertilization-frozen embryo transfer (IVF-FET). This study aims to examine the associations b…

Endometriosis is an estrogen dependent disease, which is related to infertility. Decidualization is a prerequisite for successful implantation of human embryos, and endometriosis affects the occurrence of decidualization. However, the mecha…

As a heterogeneous disease, endometriosis is associated with diagnostic delay. Delayed diagnosis, physical discomfort, hormone therapy, and inconvenience in daily life and work all contribute to a decreased quality of life for endometriosis…

INTRODUCTION: Low-grade endometrial stromal sarcoma (LGESS) is a rare malignant tumor of the uterus, characterized by slow growth. Early-stage LGESS is associated with favorable survival, but it has a high recurrence rate. The primary treat…

OBJECTIVE: To analyze the correlation between Clinical Features and Perinatal Outcomes in the population of pregnancies with adenomyosis. METHODS: This retrospective study analyzed 413 pregnant women with ultrasonography/MRI-confirmed aden…

Adenomyosis remains a challenging gynecological disorder to investigate due to the absence of in vitro models that accurately replicate endometrial tissue dynamics across the menstrual cycle. To address this gap, we established an endometri…

OBJECTIVE: The study aimed to explore the effects of platelet-rich plasma (PRP) gel on vaginal microecology and stump healing, as well as its underlying mechanism. METHODS: From December 2022 to August 2024, 100 patients who underwent lapa…

INTRODUCTION: Prolactin (PRL) plays a key role in the regulation of reproductive functions. However, its impact on outcomes in infertility women undergoing assisted reproductive technology remains unclear. This study aimed to examine the re…

To analyze the significance of endometrial thickness (EMT), endometrial volume and uterine peristalsis (UP) for forecasting the pregnancy outcome of patients with adenomyosis (ADM) undergoing frozen embryo transfer (FET). Women diagnosed wi…

The incidence of malignant tumors continues to grow. Still, with the rapid development of various diagnostic and therapeutic techniques, the survival rate of malignant tumors has been improved, and the increased survival rate has introduced…

BACKGROUND: Acupuncture and moxibustion, as traditional therapies in Chinese medicine, are widely recognized for their therapeutic effects, particularly in pain relief. Nevertheless, the exact mechanisms underlying their analgesic effects r…

BACKGROUND: The principal indicators adopted for the assessment of follicular quality are still two-dimensional ultrasound(2D-US) imaging parameters, but these do not reflect the three-dimensional morphology of follicles. We herein aimed to…

Premature ovarian failure is a prevalent gynecological endocrine disorder with an increasing incidence rate each year, impacting women's physical and mental health. The causes of POF are poorly understood, but genetic, immune, iatrogenic, e…

Current interventions for endometriosis mainly involve hormone therapies but have limited efficacy and unacceptable side effects due to the lack of selectivity to distinguish between endometriosis and endometrial tissues. Elucidating the mo…

PURPOSE: To screen drug targets of ovarian aging from a genetic perspective. METHODS: Systematic analyses were conducted with cis-expression quantitative trait loci data of druggable genes extracted as instrument variables. Summary statist…

BACKGROUND: Epithelial ovarian cancer (EOC) currently lacks highly specific biomarkers for clinical screening. This study aimed to identify and validate novel auxiliary diagnostic markers for EOC. METHODS: Through integrated analysis of tr…

UNLABELLED: Lysine-specific histone demethylase 1A (KDM1A) has emerged as an attractive therapeutic target for treating various cancers, owing to its observed overexpression. However, its function in epithelial ovarian cancer (EOC) remains …

High incidence of unexplained miscarriage (UM) limits global human reproduction. Lithium (Li) batteries are widely used but rarely recycled, causing Li to spread into environments and enter human body. Notably, the healthy effects of Li exp…