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Intravenous leiomyomatosis (IVL) is a rare entity with nonspecific presentations, often leading to diagnostic challenges. Complete surgical resection requires precise preoperative imaging to map tumor extent. This retrospective case series …

Endometriosis is frequently associated with infertility and postoperative recurrence, and fertility-sparing surgery may be considered when symptoms, endometriomas, adhesions, or deep infiltrating disease are unlikely to be adequately manage…

Diminished ovarian reserve (DOR) is characterized by a decline in oocyte quantity and/or quality and represents a growing cause of female infertility, particularly among young women, yet its pathogenesis remains incompletely understood. Dis…

The increasing prevalence of obesity, diabetes, and other metabolic disorders is driving the application of sucralose in the food industry. However, its direct effects on the reproductive function have not been sufficiently investigated. Ch…

Adenomyosis (AM) is a common gynecological disorder with high prevalence among women of childbearing age. Although hysterectomy is the definitive treatment, it is considered unsuitable for patients who wish to preserve fertility, creating a…

Gestational diabetes mellitus (GDM), is a prevalent metabolic disorder associated with placental dysfunction and adverse pregnancy outcomes. Emerging evidence points to endoplasmic reticulum (ER) stress as a potential initiating factor in G…

Phthalates (PAEs), typical endocrine-disrupting chemicals (EDCs) that accumulate in the human body to induce reproductive toxicity, have epidemiological links to endometriosis (EM), but the underlying micro-mechanisms remain unclear. Ferrop…

BACKGROUND: This study aims to use non-targeted metabolomics to analyze the metabolic characteristics of follicular fluid in patients with decreased ovarian reserve (DOR) and explore the mediating role of these metabolites in DOR and assist…

BACKGROUND: Endometriosis (EMS) is an estrogen-dependent chronic inflammatory disorder for which metabolic reprogramming has emerged as a central pathological feature. Driven by genetic, epigenetic, and microenvironmental stressors, ectopic…

Metabolic determinants of oocyte quality and embryonic development remain incompletely understood. Here, we profiled metabolites in human cumulus cells (CCs) and follicular fluid (FF), validated in two mouse models, and integrated transcrip…

PURPOSE: This study investigates metabolic profiles in follicular fluid of patients with endometriosis (EM), polycystic ovary syndrome (PCOS), tubal blockage (TB), and unexplained infertility (UEI), assessing their associations with follicu…

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

BACKGROUND: Age-related diminished ovarian reserve (DOR) exhibits marked significant individual variation. Some women of advanced age with normal ovarian reserve (NOR) achieve better reproductive outcomes than age-matched DOR patients. OBJE…

Breast cancer prognosis and treatment outcomes are shaped by intricate interplay between tumor biology, systemic comorbidities, and patient-reported functional status. This paper introduces a framework to address critical gaps in precision …

BackgroundIntracytoplasmic sperm injection (ICSI) is performed in over half of assisted reproductive technology cycles globally; however, the optimal interval between oocyte denudation and sperm injection remains undefined in clinical guide…

PurposeThe goal of optimizing electrogram acquisition in electrophysiology imaging is to minimize the number of electrodes used, determine their optimal placement, and ensure accurate imaging.MethodsWe quantitatively evaluated the impact of…

BACKGROUND: Endometriosis (EMs) is a chronic inflammatory disease often treated with blood-activating and stasis-resolving therapies. Anxiety and depression are common mental comorbidities in patients with EMs. There are no medications avai…

PurposePain-related fear (PRF) is increasingly recognized as a clinically relevant psychological factor in chronic pain, yet its role in attentional processing across varying threat levels remains unclear, particularly in functional viscera…

BackgroundManaging failure after an initial assisted reproductive technology (ART) cycle remains a significant clinical challenge. Clinicians often face a dilemma between repeating the index protocol, escalating gonadotropin (Gn) dosages, o…

PurposeTo evaluate prediction models for acute postoperative pain (AOPP) and chronic postsurgical pain (CPSP) after cancer surgery, prioritizing pain phenotype and cancer type.Patients and methodsFour databases were searched through Februar…

Endometriosis is a common gynecological disorder characterized by the ectopic growth of endometrium-like tissue outside the uterine cavity and is associated with pelvic pain, infertility, and reduced quality of life. Although several theori…

The B‑cell translocation gene 2 (BTG2), originally identified as a tumor suppressor, has been extensively studied in oncology research. However, its multifaceted functions in non‑tumor diseases are still being recognized but not entirely un…

OBJECTIVE: To identify the risk factors associated with postoperative recurrence of unusual (special-type) uterine smooth muscle neoplasia (USMN) and to construct and interpret a machine-learning model for recurrence risk. METHODS: We carr…