JongYeob Choi

No ORCID on file · 8 papers in corpus · active 2013-2024

Study types

  • article 7
  • other 1

Condition tags

  • endometriosis 8
other 2024
Dienogest attenuates STAT3 activation in ovarian endometriotic cysts
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2024.01.013

OBJECTIVE: Recent studies have suggested that endometriosis could be the result of excessive activation of signal transducer and activator of transcription 3 (STAT3), which is associated with the regulation of essential cellular mechanisms …

article 2022
Inhibition of the NLRP3 inflammasome by progesterone is attenuated by abnormal autophagy induction in endometriotic cyst stromal cells: implications for endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gaac007

The NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome is a cytosolic multi-protein complex that induces inflammation and is known to be regulated negatively by autophagy. Previous studies reported an abnormal induction of aut…

article 2021
Nuclear factor-kappa B signaling in endometriotic stromal cells is not inhibited by progesterone owing to an aberrant endoplasmic reticulum stress response: a possible role for an altered inflammatory process in endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gaab002

Endoplasmic reticulum (ER) stress serves as a key modulator of the inflammatory response by controlling nuclear factor-kappaB (NF-κB) signaling. Previous studies from our laboratory have reported an abnormal induction of ER stress linked to…

article 2019
Dienogest regulates apoptosis, proliferation, and invasiveness of endometriotic cyst stromal cells via endoplasmic reticulum stress induction
Molecular human reproduction ·doi:10.1093/molehr/gaz064

Dienogest, a specific progesterone receptor agonist, is used in the treatment of endometriosis. However, it is still unclear as to the mechanisms of therapeutic effects on endometriosis. Our recent study showed that endometriosis may be the…

article 2019
Involvement of endoplasmic reticulum stress in regulation of endometrial stromal cell invasiveness: possible role in pathogenesis of endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gaz002

Endoplasmic reticulum (ER) stress is known to reduce invasiveness in some cancer cells by inhibiting the AKT/mTOR pathway. A previous study from our laboratory suggested that ER stress is promoted by progesterone in human endometrial cells,…

article 2016
Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis
Reproduction (Cambridge, England) ·doi:10.1530/rep-16-0322

In some human cancer cells, PTEN (phosphatase and tensin homolog deleted on chromosome 10) is known to regulate autophagy induction positively through the inhibition of PI3K/AKT pathway, leading to the activation of mTOR, a major negative r…

article 2015
Dienogest enhances autophagy induction in endometriotic cells by impairing activation of AKT, ERK1/2, and mTOR
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.05.020
article 2013
Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts
Molecular human reproduction ·doi:10.1093/molehr/gat091

Mammalian target of rapamycin (mTOR) is known to be a major negative regulator of autophagy. Recent studies have shown that mTOR activity is abnormally increased in endometriotic lesions. In endometriosis, abnormal mTOR activity may contrib…